ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question
ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question
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DOI：
10.3389/fcimb.2013.00088
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发表时间：
2013-12-01
影响因子：
5.7
通讯作者：
Pardo, Julian
中科院分区：
文献类型：
--
作者：
Aguilo, Nacho;Marinova, Dessislava;Pardo, Julian
近年来，由 ESX-1 分泌系统输出的主要结核分枝杆菌毒力因子 ESAT-6 已被多个独立小组描述为促凋亡因子，在结核分枝杆菌发病机制中维持细胞凋亡的作用。这一作用得到了独立研究的支持，其中细胞凋亡已被证明是感染有毒菌株的人和小鼠肺部的标志特征。然而，细胞凋亡在分枝杆菌感染过程中的作用仍存在激烈争论。一些研究认为，减毒菌株的细胞凋亡更为明显，而强毒分枝杆菌往往会抑制这一过程，这表明细胞凋亡诱导可能是控制感染的宿主机制。在这篇综述中，我们总结了支持 ESX-1 诱导的细胞凋亡参与毒力的证据，旨在为结核分枝杆菌感染期间程序性细胞死亡的作用提供合理的论述。
The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M.tuberculosis pathogenesis. This role has been supported by independent studies in which apoptosis has been shown as a hallmark feature in human and mouse lungs infected with virulent strains. Nevertheless, the role of apoptosis during mycobacterial infection is subject to an intense debate. Several works maintain that apoptosis is more evident with attenuated strains, whereas virulent mycobacteria tend to inhibit this process, suggesting that apoptosis induction may be a host mechanism to control infection. In this review, we summarize the evidences that support the involvement of ESX-1-induced apoptosis in virulence, intending to provide a rational treatise for the role of programmed cell death during M. tuberculosis infection.