Amygdalar recruitment during anticipation of monetary rewards: an event-related fMRI study.
Amygdalar recruitment during anticipation of monetary rewards: an event-related fMRI study.
复制标题
预期金钱奖励期间杏仁核的募集：一项与事件相关的功能磁共振成像研究。
DOI：
10.1111/j.1749-6632.2003.tb07103.x
复制
发表时间：
2003
影响因子：
5.2
通讯作者：
Varnera,JeraldL
中科院分区：
文献类型：
--
作者：
Hommer,DanielW;Knutson,Brian;Fong,GraceW;Bennett,Shannon;Adams,CharlesM;Varnera,JeraldL
The involvement of the central nucleus of the amygdala (CEA) in the expression of fearful behavior and of the lateral and basolateral nuclei of the amygdala in fear cue learning have been extensively documented. However, the amygdala, s role in reward assessment and appetitive behavior has received less attention. Recently, using functional magnetic resonance imaging (fMRI), we measured blood oxygenation-dependent (BOLD) contrast in the human brain as volunteers anticipated pressing a button to gain monetary rewards or avoid punishments. 1 We found that anticipation of rewards selectively increased BOLD contrast in the nucleus accumbens (NA), whereas anticipation of punishment did not. By contrast, anticipation of both rewards and punishments recruited more dorsal regions of the striatum (eg, the medial caudate) as well as the anterior thalamus. In a second study, we observed that feedback regarding whether or not rewards were successfully obtained did not activate the striatum, but instead recruited regions of the medial frontal cortex. 2 In both of these experiments, activations of regions of the dorsal amygdala were also observed during reward anticipation. Here, using the same task, we explore incentive-related recruitment of the dorsal amygdala in greater detail. Twelve healthy volunteers (six women and six men, all right-handed, mean age 31 years) participated in the study, which was performed using a 1.5-T GE Signa magnet and an event-related design. The task consisted of 144 6-second trials during which volunteers saw one of seven shapes (cue; 250 ms), each of which indicated that they should respond to win or avoid losing different amounts of money ($5.00, $1.00, or $0.20) or that they should respond for no monetary outcome. After the cue,
