A model for Dictyostelium slug movement
A model for Dictyostelium slug movement
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DOI：
10.1006/jtbi.1999.0944
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发表时间：
1999-07-21
影响因子：
2
通讯作者：
Weijer, CJ
中科院分区：
文献类型：
--
作者：
Bretschneider, T;Vasiev, B;Weijer, CJ
网骨藻蛞蝓的运动是由其10（5）个组成细胞协调运动的结果。我们已经通过实验表明，在蛞蝓顶端的细胞显示出旋转细胞运动，而在蛞蝓后部的细胞周期性地向前移动（Siegert和Weijer，1992）。我们已经提出了这样的假设，即蛞蝓中的细胞运动是由对在尖端产生的涡卷波的趋化性控制的，所述涡卷波在蛞蝓的后部转化为扭曲涡卷波或平面波（Bretschneider等人，1995年）。所有个体细胞响应这些波的协调运动可能导致蛞蝓向前运动。我们现在通过扩展我们的土丘形成模型来测试这一假设（Bretschneider等人，1997）以包括具有不同信号传导和运动特性的两种细胞类型。所有细胞都能够传递cAMP并响应cAMP梯度而进行趋化性移动。细胞通过粘附、压力和摩擦与邻近细胞和细胞外基质相互作用。该模型可以产生稳定的涡卷波，涡卷波从段塞尖端传播到段塞后部，协调单元的向前运动，导致段塞运移。我们使用该模型来研究细胞类型的兴奋性，粘附和细胞相互作用的具体差异对蛞蝓运动的影响。(C)北京：科学出版社.
Dictyostelium slug movement results from the coordinated movement of its 10(5) constituent cells. We have shown experimentally that cells in the tip of the slug show a rotational cell movement while the cells in the back of the slug move periodically forward (Siegert & Weijer, 1992). We have put forward the hypothesis that cell movement in slugs is controlled by chemotaxis to scroll waves generated in the tip which convert to twisted scroll or planar waves in the back of the slug (Bretschneider et al., 1995). The coordinated movement of all individual cells in response to these waves could then result in forward movement of the slug. We now test this hypothesis by extending our model for mound formation (Bretschneider et al., 1997) to include two cell types with different signalling and movement properties. All cells are able to relay cAMP and move chemotactically in response to cAMP gradients. Cells interact by adhesion, pressure and friction with neighbouring cells and the extracellular matrix. The model can generate stable scroll waves propagating from the tip to the back of a slug which coordinate forward cell movement and result in slug migration. We use the model to investigate the influence of cell type specific differences in excitability, adhesion and cell interactions on slug motion. (C) 1999 Academic Press.