Diabetic kidney disease treated with a modified Shenzhuo formula derived from Traditional Chinese Medicine: a case report.
Diabetic kidney disease treated with a modified Shenzhuo formula derived from Traditional Chinese Medicine: a case report.
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DOI：
10.1016/s0254-6272(18)30051-7
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发表时间：
2017-12
影响因子：
2.6
通讯作者：
G. Jing;Chen Hongdong;Zhao Xiyan;Zhao Linhua;Tong Xiaolin
中科院分区：
文献类型：
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作者：
G. Jing;Chen Hongdong;Zhao Xiyan;Zhao Linhua;Tong Xiaolin
简介糖尿病肾病（DKD）是糖尿病最常见的微血管并发症之一，也是导致终末期肾病的主要原因。 DKD严重影响患者的生活质量，给国家带来沉重的经济负担。目前，DKD的发病机制尚不完全清楚，临床治疗主要是控制血糖、降低血压和尿蛋白。但临床效果并不理想。病例介绍一位女性患者，72岁，初诊我院内分泌科，诊断为DKD。她感到疲倦、下肢发冷、下肢抽搐、夜间尿频。她的舌头呈深紫色，有白色和黄色的苔藓，舌下有静脉曲张。辅助检查：空腹血糖5.7mmol/L，血肌酐159μmol/L，血尿素氮13.6μmol/L，血尿酸493pmol/L，血压138/65mmHg。患者接受加味参浊方【黄芪、大黄、水蛭、丹参】中药治疗7年，取得良好疗效。结论该病例为中药临床应用治疗DKD提供了具体的治疗方案和有效的参考。这可能是 DKD 的替代治疗方法。
IntroductionDiabetic kidney disease (DKD) is one of the most common microvascular complications of diabetes mellitus and is the leading cause of end-stage renal disease. DKD seriously affects the quality of life of patients and brings heavy economic burden to the country. At present, the pathogenesis of DKD is not entirely clear, and clinical treatment is mainly to control blood glucose and lower blood pressure and urine protein. However, the clinical effect is not satisfactory.Case PresentationA female patient, aged 72 years, first visited our hospital endocrinology clinic, and was diagnosed with DKD. She suffered from fatigue, cold sensation in the lower extremities, convulsion of the lower limbs and frequent urination at night. She had a dark purple tongue with white and yellow fur and sublingual varices. Accessory examinations showed that her fasting blood glucose was 5.7 mmol/L, serum creatinine 159 μmol/L, blood urea nitrogen 13.6 μmol/L, blood uric acid 493 pmol/L, and blood pressure 138/65 mm Hg. The patient received Traditional Chinese Medicine treatment of the modified Shenzhuo formula [Huangqi (Radix Astragali Mongolici), Dahuang (Radix Et Rhizoma Rhei Palmati), Shuizhi (Hirudo) and Danshen (Radix Salviae Miltiorrhizae)] for 7 years and achieved good results.ConclusionThis case provides a specific treatment plan and an effective reference for clinical application of Traditional Chinese Medicine for treating DKD. This may be an alternative treatment for DKD.