Pre-eclampsia is associated with, and preceded by, hypertriglyceridaemia: a meta-analysis
Pre-eclampsia is associated with, and preceded by, hypertriglyceridaemia: a meta-analysis
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DOI：
10.1111/1471-0528.12375
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发表时间：
2013-10-01
影响因子：
5.8
通讯作者：
Vatish, M.
中科院分区：
文献类型：
--
作者：
Gallos, I. D.;Sivakumar, K.;Vatish, M.
背景甘油三酯升高是代谢综合征、母体肥胖、母体血管炎（即系统性红斑狼疮）和糖尿病的特征。这些情况都是先兆子痫的已知危险因素。因此，高脂血症可能与先兆子痫有关，实际上，这可能先于明显疾病的存在。在这项研究中，我们确定孕妇高脂血症和先兆子痫之间的联系。搜索策略我们搜索了MEDLINE，EMBASE，Web of Science，Excerpta Medica Database，ISI Web of Knowledge，Cumulative Index to Nursing and Allied Health Literature，选择标准两名评审员独立选择了对孕妇的研究，其中测量了甘油三酯，并对妇女进行了随访，直到先兆子痫的发展，或根据先兆子痫的存在进行选择。数据收集和分析我们收集和荟萃分析的加权平均差异（WMD）的甘油三酯水平从个别研究使用的随机效应模型。主要结果我们发现了强有力的证据，从荟萃分析的24个病例对照研究（2720名妇女）先兆子痫与血清甘油三酯水平升高有关（WMD 0.78mmol/l，95%可信区间0.6-0.96，P
BackgroundElevated triglycerides are a feature of the metabolic syndrome, maternal obesity, maternal vasculitis (i.e. systemic lupus erythematosus) and diabetes mellitus. These conditions are all known risk factors for pre-eclampsia. Hypertriglyceridaemia therefore may be associated with pre-eclampsia and indeed this may precede the presence of overt disease.ObjectiveIn this study we determine the association between hypertriglyceridaemia and pre-eclampsia in pregnant women.Search strategyWe searched MEDLINE, EMBASE, Web of Science, Excerpta Medica Database, ISI Web of Knowledge, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library from inception until June 2012 and reference lists of relevant studies.Selection criteriaTwo reviewers independently selected studies on pregnant women where triglycerides were measured and women were followed up until the development of pre-eclampsia or selected on the basis of presence of pre-eclampsia and compared with controls.Data collection and analysisWe collected and meta-analysed the weighted mean differences (WMDs) of triglyceride levels from individual studies using a random effects model.Main resultsWe found strong evidence from meta-analysis of 24 case-control studies (2720 women) that pre-eclampsia is associated with higher levels of serum triglycerides (WMD 0.78mmol/l, 95% confidence interval 0.6-0.96, P