Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association.
Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association.
复制标题
青少年吸电子烟对心肺的影响：美国心脏协会的科学声明。
DOI：
10.1161/res.0000000000000544
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发表时间：
2022
影响因子：
20.1
通讯作者：
CouncilonArteriosclerosis,ThrombosisandVascularBiolo
中科院分区：
文献类型：
--
作者：
Wold,LorenE;Tarran,Robert;CrottyAlexander,LauraE;Hamburg,NaomiM;Kheradmand,Farrah;StHelen,Gideon;Wu,JosephC;AmericanHeartAssociationCouncilonBasicCardiovascularSciences;CouncilonArteriosclerosis,ThrombosisandVascularBiolo
尽管美国食品和药物管理局（fda）尚未批准电子烟作为戒烟辅助工具，但行业有时会将其产品定位为试图戒烟的成年人；然而，它们的新颖性和可定制性使它们落入了意想不到的用户手中，尤其是青少年。大多数电子烟产品的新用户从未吸过传统香烟；因此，了解电子烟使用对呼吸和心血管的影响已经成为研究界越来越感兴趣的问题。大多数研究都是针对成年电子烟使用者进行的，但这些研究参与者中的大多数要么是以前的传统吸烟者，要么是使用电子烟从传统吸烟转向吸烟者。因此，这一人群的呼吸和心血管后果不能单独归因于电子烟的使用。临床前研究已被用于研究初次使用电子烟对各种器官系统的影响；然而，几乎所有这些研究都使用了成年动物，这使得将健康影响转化为青少年存在问题。考虑到吸入任何外来物质都会对呼吸系统和心血管系统产生影响，更全面地了解毒性的途径可以帮助指导研究人员制定新的治疗策略。本科学声明的目的是为青少年使用电子烟（vaping）对心肺的影响提供重要的背景信息，指导治疗和预防策略以及未来的研究方向，并向公共政策制定者通报电子烟的短期和长期风险。
Although the US Food and Drug Administration has not approved e-cigarettes as a cessation aid, industry has at times positioned their products in that way for adults trying to quit traditional cigarettes; however, their novelty and customizability have driven them into the hands of unintended users, particularly adolescents. Most new users of e-cigarette products have never smoked traditional cigarettes; therefore, understanding the respiratory and cardiovascular consequences of e-cigarette use has become of increasing interest to the research community. Most studies have been performed on adult e-cigarette users, but the majority of these study participants are either former traditional smokers or smokers who have used e-cigarettes to switch from traditional smoking. Therefore, the respiratory and cardiovascular consequences in this population are not attributable to e-cigarette use alone. Preclinical studies have been used to study the effects of naive e-cigarette use on various organ systems; however, almost all of these studies have used adult animals, which makes translation of health effects to adolescents problematic. Given that inhalation of any foreign substance can have effects on the respiratory and cardiovascular systems, a more holistic understanding of the pathways involved in toxicity could help to guide researchers to novel therapeutic treatment strategies. The goals of this scientific statement are to provide salient background information on the cardiopulmonary consequences of e-cigarette use (vaping) in adolescents, to guide therapeutic and preventive strategies and future research directions, and to inform public policymakers on the risks, both short and long term, of vaping.