Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines
Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines
复制标题
DOI：
10.1016/j.biochi.2021.01.015
复制
发表时间：
2021-02-12
期刊：
影响因子：
3.9
通讯作者：
Wong, Eng Hwa
中科院分区：
文献类型：
--
作者：
Ahmad, Bilal;Vohra, Muhammad Sufyan;Wong, Eng Hwa
棕色和米色脂肪组织是适应性非颤抖产热的主要部位。虽然棕色和米色脂肪组织的主要致热作用已为人所知，但近年来发现，与白色脂肪组织(WAT)一样，棕色和米色脂肪组织也通过分泌各种棕色脂肪因子(Batokines)来调节代谢健康，以响应各种生理信号。这些分泌的蝙蝠激素靶向远处的器官和组织，如肝脏、心脏、骨骼肌、脑、WAT，并以自分泌、旁分泌或内分泌的方式执行各种局部和系统功能。因此，棕色和米色脂肪组织因其对其他各种器官和组织的影响而受到越来越多的关注。通过这些组织识别新的分泌因子可能有助于发现治疗各种代谢疾病的候选药物，如肥胖、2型糖尿病、骨骼畸形、心血管疾病、血脂异常。本文综述了棕色/米色脂肪组织的分泌作用，以及各种棕色/米色脂肪组织分泌因子以内分泌/旁分泌方式对其他器官和组织的代谢作用，以及以自分泌方式对棕色/米色脂肪组织本身的影响。这将为理解棕色/米色脂肪组织在改善代谢健康方面的潜在分泌作用提供洞察力。(C)2021年爱思唯尔公司和法国生物与分子生物学公司(SFBBM)。版权所有。
Brown and beige adipose tissues are the primary sites for adaptive non-shivering thermogenesis. Although they have been known principally for their thermogenic effects, in recent years, it has emerged that, just like white adipose tissue (WAT), brown and beige adipose tissues also play an important role in the regulation of metabolic health through secretion of various brown adipokines (batokines) in response to various physiological cues. These secreted batokines target distant organs and tissues such as the liver, heart, skeletal muscles, brain, WAT, and perform various local and systemic functions in an autocrine, paracrine, or endocrine manner. Brown and beige adipose tissues are therefore now receiving increasing levels of attention with respect to their effects on various other organs and tissues. Identifi-cation of novel secreted factors by these tissues may help in the discovery of drug candidates for the treatment of various metabolic disorders such as obesity, type-2 diabetes, skeletal deformities, cardiovascular diseases, dyslipidemia. In this review, we comprehensively describe the emerging secretory role of brown/beige adipose tissues and the metabolic effects of various brown/beige adipose tissues secreted factors on other organs and tissues in endocrine/paracrine manners, and as well as on brown/beige adipose tissue itself in an autocrine manner. This will provide insights into understanding the potential secretory role of brown/beige adipose tissues in improving metabolic health.(c) 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.