HLA Haplotype Frequency Estimation from Real-Life Data with the Hapl-o-Mat Software
HLA Haplotype Frequency Estimation from Real-Life Data with the Hapl-o-Mat Software
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DOI：
10.1007/978-1-4939-8546-3_19
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发表时间：
2018-01-01
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影响因子：
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通讯作者：
Schmidt, Alexander H.
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文献类型：
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作者：
Sauter, Juergen;Schafer, Christian;Schmidt, Alexander H.
HLA单倍型频率可用于各种情况。这些数据通常是通过有针对性的分型或对大量人群特异性基因型样本进行统计分析而获得的家庭系谱数据。由于后一种方法的现有工具缺乏处理造血干细胞供体登记中基因型数据的数量、模糊性和不均匀性的能力，我们开发了Hapl-o-Mat来缓解这些特定的缺点。
HLA haplotype frequencies are of use in a variety of settings. Such data is typically derived either from family pedigree data by targeted typing or statistical analysis of large population-specific genotype samples. As established tools for the latter approach lacked ability to treat the amount, ambiguity, and inhomogeneity found in genotype data in hematopoietic stem cell donor registries, we developed Hapl-o-Mat to alleviate these specific shortcomings.