Improvement of stenting therapy with a silicon carbide coated tantalum stent
Improvement of stenting therapy with a silicon carbide coated tantalum stent
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DOI：
10.1007/bf00058566
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发表时间：
1996-05-01
影响因子：
3.7
通讯作者：
Schaldach, M
中科院分区：
文献类型：
--
作者：
Amon, M;Bolz, A;Schaldach, M
最先进的心血管支架材料是体积特性和表面相关特性之间的妥协。因此，这两个特征的不足导致支架治疗的严重限制。除了当前支架材料的x线可视性不理想，这阻碍了在植入过程中对支架进行精确的血管造影控制外，血液相容性不足会导致亚急性血管闭塞，尽管使用了严格的抗凝药物。此外，出血并发症的发生进一步限制了治疗的成功。因此，有必要开发一种新型的冠状动脉支架，改善支架的体积和表面的材料性能。这是通过混合概念实现的。该支架由钽制成，具有较高的固有放射性不透明度。该支架涂有非晶碳化硅，优化了血液相容性。开发了一种适当的沉积工艺，以最大限度地提高涂层的附着力。在体外和体内研究了非晶碳化硅作为冠状动脉支架的适用性。
State of the art cardiovascular stent materials are a compromise between bulk properties and surface related properties. As a consequence, deficiencies in both characteristics lead to serious limitations of stenting therapy. Beside a dissatisfying X-ray visibility of current stent materials, which hinders precise angiographic control of the stent during implantation, insufficient hemocompatibility causes subacute vessel occlusions despite stringent anticoagulant medication. Additionally, bleeding complications result which further limit the therapeutical success. Therefore it is essential to develop a new coronary stent with improved material properties for the bulk of the stent and its surface. This is realized by a hybrid concept. The stent is manufactured from tantalum, having a high inherent radio-opacity. The stent is coated with amorphous silicon carbide, optimized for hemocompatibility. An appropriate deposition technology to maximize coating adhesion was developed. Amorphous silicon carbide was investigated in vitro and in vivo to assess its suitability for coronary stents.