Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans.
Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans.
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DOI：
10.1152/ajpregu.00057.2015
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发表时间：
2016-05
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影响因子：
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通讯作者：
T. Yoneshiro;Mami Matsushita;Satoshi Nakae;T. Kameya;Hiroki Sugie;Shigeho Tanaka;M. Saito
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文献类型：
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作者：
T. Yoneshiro;Mami Matsushita;Satoshi Nakae;T. Kameya;Hiroki Sugie;Shigeho Tanaka;M. Saito
棕色脂肪组织 (BAT) 有助于人体全身能量消耗 (EE)，尤其是冷诱导产热 (CIT)。尽管众所周知 EE 和 CIT 随季节变化，但它们与 BAT 的关系尚未得到研究。在本研究中，我们通过随机交叉设计研究了 BAT 对 EE/CIT 季节性变化以及对冷暴露的热反应的影响。 45 名健康男性志愿者参与其中，并通过正电子发射断层扫描和计算机断层扫描评估了他们的 BAT。 CIT，即 27°C 下和 19°C 冷暴露 2 小时后的 EE 差异，与夏季相比，冬季显着增加，代谢活跃的 BAT 受试者（高 BAT，185.6 kcal/d，18.3 kcal/d，P<0.001）高于没有代谢活跃 BAT（低 BAT，90.6 kcal/d，-46.5 kcal/d， P<0.05）。多元回归分析显示季节和 BAT 对 CIT 存在显着的交互作用（P<0.001）。冬季高BAT组中，寒冷引起的前额区域和靠近BAT沉积物的锁骨上区域的鼓室温度（Tty）和皮肤温度（Tskin）下降幅度小于低BAT组，但夏季则不然。相比之下，两个季节中，两组中远离 BAT 的锁骨下和周围区域的 Tskinin 下降相似。总之，CIT 从夏季到冬季以 BAT 依赖性方式增加，与寒冷引起的 Tty/Tskin 变化平行，表明 BAT 在人类对寒冷暴露的生热和热反应的季节性变化中发挥作用。
Brown adipose tissue (BAT) contributes to whole-body energy expenditure (EE), especially cold-induced thermogenesis (CIT), in humans. Although it is known that EE and CIT vary seasonally, their relationship with BAT has not been investigated. In the present study, we examined the impact of BAT on seasonal variations of EE/CIT and thermal responses to cold exposure in a randomized crossover design. Forty-five healthy male volunteers participated, and their BAT was assessed by positron emission tomography and computed tomography. CIT, the difference of EE at 27ºC and after 2-h cold exposure at 19ºC, significantly increased in winter compared to summer, being greater in subjects with metabolically active BAT (High BAT, 185.6 kcal/d, 18.3 kcal/d, P<0.001) than those without (Low BAT, 90.6 kcal/d, -46.5 kcal/d, P<0.05). Multivariate regression analysis revealed a significant interaction effect between season and BAT on CIT (P<0.001). The cold-induced drop of tympanic temperature (Tty) and skin temperature (Tskin) in the forehead region and in the supraclavicular region close to BAT deposits were smaller in the High BAT group than in the Low BAT group in winter but not in summer. In contrast, the drop of Tskinin the subclavicular and peripheral regions distant from BAT was similar in the two groups in both seasons. In conclusion, CIT increased from summer to winter in a BAT-dependent manner, paralleling cold-induced changes in Tty/Tskin, indicating a role of BAT in seasonal changes in the thermogenic and thermal responses to cold exposure in humans.