HIV incidence among injection drug users in New York City, 1990 to 2002: Use of serologic test algorithm to assess expansion of HIV prevention services
HIV incidence among injection drug users in New York City, 1990 to 2002: Use of serologic test algorithm to assess expansion of HIV prevention services
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DOI：
10.2105/ajph.2003.036517
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发表时间：
2005-08-01
影响因子：
12.7
通讯作者：
Friedman, SR
中科院分区：
文献类型：
--
作者：
Jarlais, DC;Perlis, T;Friedman, SR
目标.我们试图估计1990年至2002年纽约市注射吸毒者（IDUs）中的HIV发病率，以评估扩大注射器交换服务的影响。注射器交换大大增加，在此期间，从250000至300000注射器每年交换。血清样本来自对3651名注射吸毒者的连续横断面调查。使用近期HIV血清转换的血清学检测算法（STARHS）检测试剂盒检测HIV阳性样本，以识别近期HIV感染并估计HIV发病率。与其他发病率研究的一致性被用来评估STARHS的优势和局限性。艾滋病毒感染率从1990-1992年的3.55/100人年（PYAR）下降到1993-1995年的2.63/100 PYAR，1996-1998年的1.05/100 PYAR，1999-2002年的0.77/100 PYAR（P
Objectives. We sought to estimate HIV incidence among injection drug users (IDUs) in New York City from 1990 to 2002 to assess the impact of an expansion of syringe exchange services. Syringe exchange increased greatly during this period, from 250000 to 3000000 syringes exchanged annually.Methods. Serum samples were obtained from serial cross-sectional surveys of 3651 IDUs. HIV-positive samples were tested with the Serologic Test Algorithm for Recent HIV Seroconversion (STARHS) assay to identify recent HIV infections and to estimate HIV incidence. Consistency with other incidence studies was used to assess strengths and limitations of STARHS.Results. HIV incidence declined from 3.55/100 person-years at risk (PYAR) from 1990-1992, to 2.63/100 PYAR from 1993-1995, to 1.05/100 PYAR from 1996-1998, and to 0.77/100 PYAR from 1999-2002 (P