Physical activity can improve cognition in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials.
Physical activity can improve cognition in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials.
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体力活动可以改善阿尔茨海默病患者的认知：随机对照试验的系统回顾和荟萃分析
DOI：
10.2147/cia.s169565
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发表时间：
2018
影响因子：
3.6
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Du Z;Li Y;Li J;Zhou C;Li F;Yang X
阿尔茨海默病（Alzheimer 's disease， AD）以记忆、学习等认知功能衰退为主要特征，发病率高，治疗方案药物疗效差。本研究对随机对照试验（RCTs）进行了系统回顾和荟萃分析，以评估运动对AD患者认知功能的影响。检索了文献数据库（PubMed、Cochrane Library and Embase和Web of Science）和四个中文数据库（万方数据、CBM、中国知网和VIP），以确定1960年1月1日至2018年1月1日期间以任何语言发表的rct。仅纳入同行评审的文章和随机对照试验。收集的数据由评审经理（5.3）进行分析。总的来说，从13项随机对照试验中纳入了869名被诊断为AD的患者。干预组患者接受单纯的运动干预和认知测试。虽然研究之间在干预方法和认知测量方面存在异质性，但meta分析（7项研究）支持体育活动对AD患者认知功能的积极影响（平均差异[MD] =2.53, 95% CI=0.84 ~ 4.22，总体效果检验：Z=2.93 [P=0.003]）。八项研究表明，锻炼可以改善阿尔茨海默病患者的认知功能。然而，其余五项研究并未显示运动对阿尔茨海默病患者的认知功能有有益影响。本荟萃分析和系统评价表明，运动干预可能改善阿尔茨海默病的认知功能或减缓认知能力下降；然而，这种关系在所有研究中并不总是正确的。未来需要具有明确干预标准、大样本和长期随访的随机对照试验来证明运动对AD患者认知功能的益处。
Alzheimer’s disease (AD) is mainly characterized by decline of cognitive functions such as memory and learning, which has a high prevalence and poor drug efficacy in treatment regimes. A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to evaluate the effectiveness of exercise on cognitive function in patients diagnosed with AD. The bibliographic databases (PubMed, Cochrane Library and Embase, and Web of Science) and four Chinese databases (Wanfang data, CBM, CNKI, and VIP) were searched to identify RCTs published in any language between January 1, 1960, and January 1, 2018. Only peer-reviewed articles and RCTs were included. The collected data were analyzed by Review Manager (5.3). Overall, 869 patients diagnosed with AD were included from 13 RCTs. Patients in the intervention group received pure exercise interventions and a cognitive test. Although there was heterogeneity in intervention methods and cognitive measures among studies, meta-analysis (seven studies) supports positive effects of physical activity on cognitive function of patients with AD (mean difference [MD] =2.53, the 95% CI=0.84 to 4.22, test for overall effect: Z=2.93 [P=0.003]). Eight studies demonstrated that exercise improves cognitive function for individuals with AD. However, the remaining five studies did not display a beneficial effect of exercise on cognitive function in patients with AD. This meta-analysis and systematic review indicated that exercise intervention might improve the cognitive function of AD or slow down the decline of cognition; however, this relationship was not always true across studies. RCTs with clear intervention criteria, large samples, and long-term follow-up are needed in the future to demonstrate the benefits of exercise for cognitive function in AD patients.