RADIATION-THERAPY OF 9L RAT-BRAIN TUMORS
RADIATION-THERAPY OF 9L RAT-BRAIN TUMORS
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DOI：
10.1016/0360-3016(81)90136-x
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发表时间：
1981-01-01
影响因子：
7
通讯作者：
MORANTZ, RA
中科院分区：
文献类型：
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作者：
HENDERSON, SD;KIMLER, BF;MORANTZ, RA
研究了放射治疗对正常大鼠和9L脑肿瘤细胞负荷大鼠的影响。正常大鼠头部单次照射1000 ~ 2700 R，急性照射2100 R， 8 ~ 12天死亡。在1850-1950 R的范围内，大约30%的动物存活超过12天；当暴露量< 1850 R时，所有动物都存活了急性辐射效应；中位生存时间（MST）随暴露减少而增加。我们还研究了以下三种不同的辐射方案：2100 R或3000 R分为10等分，3000 R分为6等分，每一种方案在2周的时间内实施。第一个时间表产生的MST为100美元1/2年；其他时间表产生的MST较低（分别为192天和145天）。在接种肿瘤后18-28天，采用单次和分次放射治疗的正常大鼠的生存反应相似。单次和分次放射治疗可延长肿瘤负荷大鼠的生存期。这种延长与剂量呈线性关系；但仅最低限度地依赖于接种后（7-12天）开始治疗的时间，或取决于所使用的分馏计划。与正常动物一样，当施加一个因子（1.9）时，单次暴露和分次暴露获得的反应相似。所有携带肿瘤的动物在正常受辐射大鼠中观察到的死亡时间之前死亡。因此，9L脑胶质瘤大鼠脑肿瘤模型可用于放射治疗和辅助治疗新治疗方案的临床前实验研究。
The effects of radiation therapy on normal rats and on rats burdened with 9L brain tumor cells were studied. The heads of normal rats were X-irradiated with single exposures ranging from 1000-2700 R. Following acute exposures > 2100 R, all animals died in 8-12 days. Approximately 30% of the animals survived beyond 12 days over the range of 1850-1950 R; following exposures < 1850 R, all animals survived the acute radiation effects; median survival times (MST) increased with decreasing exposure. The following 3 fractionated radiation schedules were also studied: 2100 R or 3000 R in 10 equal fractions, and 3000 R in 6 equal fractions, each schedule being administered over a 2 wk period. The 1st schedule produced a MST of > 1 1/2 yr; the other schedules produced MST that were lower (192 and 145 days, respectively). By applying a factor of 1.9, similar survival responses of normal rats were obtained with single as with fractionated radiation 18-28 days after tumor inoculation. Single and fractionated radiation therapy resulted in a prolongation of survival of tumor-burdened rats. This prolongation was linearly dependent upon the dose; but only minimally dependent upon the time after inoculation (7-12 days) at which therapy was initiated, or upon the fractionation schedule that was used. As with normal animals, similar responses were obtained with single as with fractionated exposures when a factor (1.9) was applied. All tumor-bearing animals died prior to the time that death was observed in normal, irradiated rats. Thus, the 9L gliosarcoma rat brain tumor model can be used for the preclinical experimental investigation of new therapeutic schedules involving radiation therapy and adjuvant therapies.