Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions.
Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions.
复制标题
在 CVD 和 T2D 条件下，人类胫骨骨膜皮质的微观结构异常通过组织学检查是明显的，但 HR-pQCT 则不明显。
DOI：
10.1016/j.medntd.2021.100062
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发表时间：
2021
影响因子：
--
通讯作者：
Kazakia,GalateiaJ
中科院分区：
文献类型：
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作者：
Garita,Barbara;Maligro,Jenna;Sadoughi,Saghi;Wu,PoHung;Liebenberg,Ellen;Horvai,Andrew;Link,ThomasM;Kazakia,GalateiaJ
皮质骨微结构缺陷可能会增加心血管疾病和糖尿病患者的骨折风险。高分辨率外周定量计算机断层扫描（HR-pQCT）能够进行体内微观结构表征，但其可视化重要生物学特征的能力有限。我们对来自6名患有心血管疾病（CVD）和2型糖尿病（T2D）的供体的胫骨远端骨样本进行了组织学分析和HR-pQCT成像。组织学（而非HR-pQCT）确定了先前未记录的可能导致皮质骨脆性的形态病理学缺陷。这些观察结果可能为改善HR-pQCT微观结构表征以及深入了解皮质骨降解机制提供指导。
Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.