Transcranial Electrical Stimulation Modifies the Neuronal Response to Psychosocial Stress Exposure
Transcranial Electrical Stimulation Modifies the Neuronal Response to Psychosocial Stress Exposure
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DOI：
10.1002/hbm.22434
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发表时间：
2014-08-01
影响因子：
4.8
通讯作者：
Kirschbaum, Clemens
中科院分区：
文献类型：
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作者：
Antal, Andrea;Fischer, Thomas;Kirschbaum, Clemens
压力是我们社会日常生活的一个持续特征，在引发几种慢性疾病方面发挥着作用。因此，有一个持续的需要，以发展新的方法，以管理应激反应。右侧内侧前额叶皮层（mPFC）的调节功能经常被影像学研究报道在心理社会应激情况下。在这里，我们研究了通过阴极和阳极经颅直流电刺激（tDCS）进行的抑制性和兴奋性预处理刺激对心理社会应激相关行为指标和生理因素的影响，包括唾液中的皮质醇水平和脑灌注的变化。在进行Trier社会压力测试（TSST）之前，在健康受试者的右侧mPFC上施加20分钟的真实或假tDCS。采用伪连续动脉自旋标记法（pCASL）测量刺激期间和TSST后的区域脑血流量（rCBF）。比较不同刺激条件的影响，在阳极刺激时，我们发现右侧mPFC的rCBF高于假性刺激，而在右侧杏仁核，PFC高于阴极刺激。完成TSST后，唾液皮质醇水平在阳极组降低，在阴极组升高。行为应激指标显示应激水平升高，但各组间无显著差异。在这项研究中，我们首次深入了解了通过前额叶tDCS介导社会心理应激反应的神经元机制。(C) 2013 Wiley期刊公司
Stress is a constant characteristic of everyday life in our society, playing a role in triggering several chronic disorders. Therefore, there is an ongoing need to develop new methods in order to manage stress reactions. The regulatory function of right medial-prefrontal cortex (mPFC) is frequently reported by imaging studies during psychosocial stress situations. Here, we examined the effects of inhibitory and excitatory preconditioning stimulation via cathodal and anodal transcranial direct current stimulation (tDCS) on psychosocial stress related behavioral indicators and physiological factors, including the cortisol level in the saliva and changes in brain perfusion. Twenty minutes real or sham tDCS was applied over the right mPFC of healthy subjects before the performance of the Trier Social Stress Test (TSST). Regional cerebral blood flow (rCBF) was measured during stimulation and after TSST, using pseudo-continuous arterial spin labeling (pCASL). Comparing the effect of the different stimulation conditions, during anodal stimulation we found higher rCBF in the right mPFC, compared to the sham and in the right amygdala, superior PFC compared to the cathodal condition. Salivary cortisol levels showed a decrease in the anodal and increase in cathodal groups after completion of the TSST. The behavioral stress indicators indicated the increase of stress level, however, did not show any significant differences among groups. In this study we provide the first insights into the neuronal mechanisms mediating psychosocial stress responses by prefrontal tDCS. (C) 2013 Wiley Periodicals, Inc.