CAAX-box protein, prenylation process and carcinogenesis.
CAAX-box protein, prenylation process and carcinogenesis.
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DOI：
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发表时间：
2009-05
影响因子：
2.2
通讯作者：
Juehua Gao;J. Liao;Guang-Yu Yang
中科院分区：
文献类型：
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作者：
Juehua Gao;J. Liao;Guang-Yu Yang
CAAX蛋白广泛参与全球细胞功能，如增殖、分化和致癌。作为一种重要的生物活性调节因子，通过蛋白质预烯基化进行的信号转导是大多数CAAX蛋白功能的关键步骤，尤其是将这些CAAX蛋白锚定在细胞膜系统上。随着对这一过程中信号转导和细胞内信息传递的分子机制有了更好的理解，CAAX蛋白的预烯基化可能对阐明致癌中的生物事件并提供选择性地阻断允许致癌的下游信号级联反应具有特别重要的意义。在这里，我们主要关注临床上重要的CAAX box蛋白的前烯基化过程，以及它们在癌症发生中作为生物标志物或预防/治疗靶点的潜力。
CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and carcinogenesis. As an important modulator of biological activity, signal transduction via protein prenylation is a crucial step for most CAAX protein functions, particularly for anchoring these CAAX proteins to cellular membrane system. With a better understanding of the molecular mechanisms of signal transduction and intracellular messaging in this process, CAAX protein prenylation may be of particular importance for elucidating the biologic events in carcinogenesis and provide potential approaches of selectively blocking the downstream signal cascade that allows carcinogenesis. Here, we mainly focus on the prenylation process of the clinically important CAAX box proteins, and their potential as a biomarker or preventive/therapeutic target in carcinogenesis.