Transcription control: Repressed repeats express themselves
Transcription control: Repressed repeats express themselves
复制标题
转录控制：被抑制的重复表达自己
DOI：
10.1016/s0960-9822(06)00408-8
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发表时间：
1997
期刊：
影响因子：
9.2
通讯作者：
A. Wolffe
中科院分区：
文献类型：
--
作者：
A. Wolffe
多拷贝转基因在植物、果蝇和哺乳动物中表达很低；这种抑制可以通过减少拷贝数来缓解，导致染色质重塑和转录激活。宿主防御机制监测基因组中的重复序列，调节其染色质包装和功能。
Multi-copy transgenes are poorly expressed in plants,Drosophilaand mammals; this repression is relieved by reducing copy number, leading to chromatin remodeling and transcriptional activation. Host defense mechanisms monitor repeated sequences in the genome, modulating their chromatin packaging and functional capabilities.