THEORETICAL AND METHODOLOGICAL CONSIDERATIONS ON DRUG DISCRIMINATION-LEARNING
THEORETICAL AND METHODOLOGICAL CONSIDERATIONS ON DRUG DISCRIMINATION-LEARNING
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DOI：
10.1007/bf00421388
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
JANSSEN, PAJ
中科院分区：
文献类型：
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作者：
COLPAERT, FC;NIEMEGEERS, CJE;JANSSEN, PAJ
描述了一种方法，其允许评估药物的辨别刺激特性，以及安非他明（0.16mg/kg，s.c.），氯氮卓（5 mg/kg，口服）、地昔帕明（5 mg/kg，皮下），和氟哌啶醇（0.02mg/kg，s.c.）产生辨别性刺激复合物（DSC）的能力得到证实。该方法产生明确的数据，具体涉及到药物的歧视学习，而不可能混淆状态依赖的影响。设计实验程序，以便提供调节药物作用的操作性反应的适当测量。
A method is described which allows the assessment of discriminative stimulus properties of drugs, and the ability of amphetamine (0.16 mg/kg, s.c.), chlordiazepoxide (5 mg/kg, orally), desipramine (5 mg/kg, s.c.), and haloperidol (0.02 mg/kg, s.c.) to produce a discriminative stimulus complex (DSC) is evidenced. The method yields clear-cut data that are specifically related to drug discrimination learning without being possibly confounded by state dependent effects. The experimental procedure is designed so as to provide an appropriate measurement of operant response modulating drug effects.