Fluorescent pattern recognition of metal ions by nanoparticles of bovine serum albumin as a chemical nose/tongue
Fluorescent pattern recognition of metal ions by nanoparticles of bovine serum albumin as a chemical nose/tongue
复制标题
牛血清白蛋白纳米粒子作为化学鼻/舌对金属离子的荧光模式识别
作者：
Fan Yu-Lin;Lu Yi-Fan;Ding Xu-Yin;Wang Nai-Hong;Xu Feng;Shi Guoyue;Zhang Min
基于牛血清白蛋白纳米颗粒（BSANsn）的仿生化学鼻/舌传感器阵列已被开发用于生物流体中金属离子的荧光模式识别。三种类型的BSANsn（BSANs 10、BSANs 20和BSANs 40）在478/526 nm处显示出相同的激发/发射峰。根据不同的荧光变化，传感器阵列显示特定的荧光响应模式取决于金属离子。通过主成分分析（PCA），发现该传感器阵列可以在低至10 μM的浓度下清晰区分18种金属离子。此外，传感器可以区分生物流体中不同浓度的金属离子和不同种类或价态的混合金属离子。此外，与传统的ICP-AES方法得到的结果一致。
A sensor array mimicking a chemical nose/tongue based on bovine serum albumin nanoparticles (BSANsn) has been developed for the fluorescence pattern recognition of metal ions in biofluids. Three types of BSANsn (BSANs10, BSANs20, and BSANs40) show the same excitation/emission peak at 478/526 nm. According to the differential fluorescence variation, the sensor array shows particular fluorescence response patterns depending upon metal ions. Upon principal component analysis (PCA), it was found that the sensor array can distinguish 18 metal ions clearly at a concentration of as low as 10 μM. Moreover, different concentrations of metal ions and mixed metal ions of diverse kinds or valence states can be differentiated by the sensor in biofluids. In addition, the results were well consistent with those obtained with the traditional ICP-AES method.