Characterization of Charge Separation in the Array of Micromachined UltraSonic Electrospray (AMUSE) Ion Source for Mass Spectrometry
Characterization of Charge Separation in the Array of Micromachined UltraSonic Electrospray (AMUSE) Ion Source for Mass Spectrometry
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DOI：
10.1016/j.jasms.2009.05.006
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发表时间：
2009-09-01
影响因子：
3.2
通讯作者：
Fedorov, Andrei G.
中科院分区：
文献类型：
--
作者：
Forbes, Thomas P.;Dixon, R. Brent;Fedorov, Andrei G.
据报道，对微机械超声电喷雾 (AMUSE) 离子源阵列中电荷分离的影响进行了初步研究，以了解电离机制并提高分析物电离效率和操作稳定性。在仅 RF 模式下，由于随机电荷波动，AMUSE 平均会喷射出相同数量的微带正电和微带负电的液滴，导致分析物电离效率低下。喷嘴孔处的电荷分离是通过施加外部电场来实现的。通过使反电极靠近喷嘴阵列，可以在相对较低的直流电势下施加强电场。通过许多电极/电势配置已经证明，增加电荷分离可以改善信号丰度、信噪比和信号稳定性。 (J Am Soc Mass Spectrom 2009, 20, 1684-1687) (C) 2009 美国质谱学会
An initial investigation into the effects of charge separation in the Array of Micromachined UltraSonic Electrospray (AMUSE) ion source is reported to gain understanding of ionization mechanisms and to improve analyte ionization efficiency and operation stability. In RF-only mode, AMUSE ejects, on average, an equal number of slightly positive and slightly negative charged droplets due to random charge fluctuations, providing inefficient analyte ionization. Charge separation at the nozzle orifice is achieved by the application of an external electric field. By bringing the counter electrode close to the nozzle array, strong electric fields can be applied at relatively low DC potentials. It has been demonstrated, through a number of electrode/electrical potential configurations, that increasing charge separation leads to improvement in signal abundance, signal-to-noise ratio, and signal stability. (J Am Soc Mass Spectrom 2009, 20, 1684-1687) (C) 2009 American Society for Mass Spectrometry