Axonal transport and neurodegenerative disease: can we see the elephant?
Axonal transport and neurodegenerative disease: can we see the elephant?
复制标题
DOI：
10.1016/j.pneurobio.2012.03.006
复制
发表时间：
2012-12
影响因子：
6.7
通讯作者：
Goldstein, Lawrence S. B.
中科院分区：
文献类型：
--
作者：
Goldstein, Lawrence S. B.
虽然轴突运输缺陷是某些神经退行性疾病的始发或进展的一部分，但这些缺陷在疾病发展中的确切作用却鲜为人知。因此，在这篇文章中，我将重点讨论轴突运输缺陷在HD和AD中的可能作用，而不是列举已经得到良好评价的证据，即疾病中存在运输缺陷。(1)在HD和AD中，轴突运输的改变是否由突变或改变的蛋白质的正常功能引起，和/或这种运输的改变是否由于多肽或蛋白质的有毒聚集体的形成而发生？(2)轴突运输的改变是否与HD和AD的原因有关，或者它们是由疾病诱导引起的其他细胞缺陷的早期或晚期后果？
Although it is well established that axonal transport defects are part of the initiation or progression of some neurodegenerative diseases, the precise role of these defects in disease development is poorly understood. Thus, in this article, rather than enumerate the already well-reviewed evidence that there are transport deficits in disease, I will focus on a discussion of two crucial and unanswered questions about the possible role of axonal transport defects in HD and AD. (1) Are alterations in axonal transport caused by changes in the normal function of proteins mutated or altered in HD and AD and/or do such alterations in transport occur as a result of the formation of toxic aggregates of peptides or proteins? (2) Do alterations in axonal transport contribute to the causes of HD and AD or are they early, or late, secondary consequences of other cellular defects caused by disease-induction?
登录
查看更多内容
影响因子：
64.8
作者：
Israel, Mason A.;Yuan, Shauna H.;Bardy, Cedric;Reyna, Sol M.;Mu, Yangling;Herrera, Cheryl;Hefferan, Michael P.;Van Gorp, Sebastiaan;Nazor, Kristopher L.;Boscolo, Francesca S.;Carson, Christian T.;Laurent, Louise C.;Marsala, Martin;Gage, Fred H.;Remes, Anne M.;Koo, Edward H.;Goldstein, Lawrence S. B.
通讯作者：
Goldstein, Lawrence S. B.
影响因子：
5.3
作者：
Her, Lu-Shiun;Goldstein, Lawrence S. B.
通讯作者：
Goldstein, Lawrence S. B.
DOI：
10.1073/pnas.0908953107
发表时间：
2010-01-26
影响因子：
11.1
作者：
Jiang, Ying;Mullaney, Kerry A.;Nixon, Ralph A.
通讯作者：
Nixon, Ralph A.
影响因子：
9.2
作者：
Horiuchi, D;Barkus, RV;Saxton, WM
通讯作者：
Saxton, WM
影响因子：
3.5
作者：
Engelender, S;Sharp, AH;Ross, CA
通讯作者：
Ross, CA