Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects
Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects
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DOI：
10.1017/s0033291720002822
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发表时间：
2022-04-01
影响因子：
6.9
通讯作者：
Kircher，Tilo
中科院分区：
文献类型：
--
作者：
Nenadic，Igor;Meller，Tina;Kircher，Tilo
背景分裂型是精神病易感性的一个假定的风险表型，但其遗传结构与精神分裂症的重叠知之甚少。（用SPQ-B评估）与精神分裂症的多基因风险评分（PRS）相关，来自FOR 2107多中心研究的非临床受试者和1133名献血者的第二个样本。结果我们没有发现精神分裂症PRS与整体SPQ或特定维度得分的相关性，也不与从SPQ（解决尺度间方差）导出的经调整的体型评分相关。此外，情感障碍（双相情感障碍和抑郁症）的PRS没有显着相关的aboutotypy.ConclusionsThis重要的负面发现表明，尽管假设的连续性aboutotypy和精神分裂症，aboutotypy可能会分享较少的遗传风险与精神分裂症比以前假设的（可能较少相比，精神病样的经验）。
BackgroundSchizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood.MethodsWe tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors.ResultsWe did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy.ConclusionsThis important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).