CA 125 serum levels correlated with second-look operations among ovarian cancer patients.
CA 125 serum levels correlated with second-look operations among ovarian cancer patients.
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CA 125 血清水平与卵巢癌患者的二次手术相关。
DOI：
10.1097/00006250-198605000-00016
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发表时间：
1986
影响因子：
7.2
通讯作者：
R. Bast
中科院分区：
文献类型：
--
作者：
J. Berek;R. Knapp;G. Malkasian;P. Lavin;C. Whitney;J. Niloff;R. Bast
ca125是许多上皮性卵巢癌表达的抗原决定因子，在血清中使用固相免疫放射测定法进行测定。我们对55名临床缓解患者的血清进行了前瞻性研究，这些患者在化疗后接受了二次检查手术以评估疾病状态。所有患者在复诊手术前一周内进行CA - 125检测。24例（44%）患者无组织学或细胞学证据，7例（13%）患者有镜下病变，13例（24%）患者有1 mm至1.5 cm的病变，10例（18%）患者肿瘤最大尺寸大于或等于1.5 cm。24例二次检查阴性患者CA 125抗原水平均为阳性（大于或等于35u /mL），而20例小于1.5 cm的患者中有6例（30%），大于或等于1.5 cm的患者中有6例（60%）（P < 0.0001）。所有12例CA 125抗原水平升高（大于或等于35 U/mL）的患者均在复诊手术时发现疾病。因此，在这种情况下，CA 125阳性滴度（大于或等于35 U/mL）的预测值为100%。CA 125抗原水平阴性（低于35 U/mL）的预测值为56%，即在44%的二次检查呈阳性的患者中，该试验不能排除疾病的存在。与至少一个既往阴性抗原水平相关的最大肿瘤大小为1.9 cm。（摘要删节250字）
CA 125, which is an antigenic determinant expressed by many epithelial ovarian cancers, is measured in serum using a solid phase immunoradiometric assay. Sera from 55 patients who were in clinical remission and underwent a second-look operation to assess disease status after chemotherapy were studied prospectively. All patients had the CA 125 assay performed within one week before their second-look operation. Twenty-four patients (44%) had no histologic or cytologic evidence of disease, seven patients (13%) had microscopic disease, 13 patients (24%) had disease measuring 1 mm to 1.5 cm, and ten patients (18%) had disease greater than or equal to 1.5 cm in maximum tumor dimension. None of the 24 patients with a negative second-look operation had a positive CA 125 antigen level (greater than or equal to 35 U/mL), compared with six of 20 patients (30%) with less than 1.5 cm disease, and six of ten (60%) with greater than or equal to 1.5 cm disease (P less than .0001). All 12 patients with an elevated CA 125 antigen level (greater than or equal to 35 U/mL) had disease discovered at their second-look operation. Thus, in this setting the predictive value of a positive CA 125 titer (greater than or equal to 35 U/mL) was 100%. The predictive value of a negative CA 125 antigen level (less than 35 U/mL) was 56%, ie, the test did not exclude the presence of disease in 44% of patients with a positive second look. The maximum tumor size associated with at least one prior negative antigen level was 1.9 cm.(ABSTRACT TRUNCATED AT 250 WORDS)