Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy
Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy
复制标题
将碳点限制在超薄层状双氢氧化物上，实现同时三模式生物成像和光热治疗
DOI：
10.1016/j.talanta.2018.02.093
复制
发表时间：
2018-07-01
期刊：
影响因子：
6.1
通讯作者：
Zhou, Shuyun
中科院分区：
文献类型：
--
作者：
Weng, Yangziwan;Guan, Shanyue;Zhou, Shuyun
开发用于癌症诊断和治疗的多功能纳米载体是一个巨大的挑战。本文通过红色发射碳点(CDS)、吲哚青绿(ICG)与超薄层状双氢氧化物(ULDHs)的简单自组装，制备了用于三模荧光/光声/双光子生物成像和有效光热治疗的多功能CDS/ICG-uLDHs纳米载体。由于ICG在自组装过程中形成了J-聚集体，CDS/ICG-uLDHs能够稳定光热剂ICG，提高其光热效率。此外，uLDHs独特的限制效应延长了Cd的荧光寿命，有利于生物成像。考虑到良好的体内外光疗和多模式成像效果，本工作为构建多功能肿瘤治疗纳米载体系统提供了一个有前景的平台。
It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.