Drosophila mechanotransduction -: Linking proteins and functions
Drosophila mechanotransduction -: Linking proteins and functions
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DOI：
10.4161/fly.4990
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发表时间：
2007-07-01
期刊：
影响因子：
1.2
通讯作者：
Goepfert, Martin C.
中科院分区：
文献类型：
--
作者：
Albert, Joerg T.;Nadrowksi, Bjoern;Goepfert, Martin C.
触觉、重力和声音的感觉都依赖于专门的离子通道，这些离子通道将机械刺激力转化为电信号。这些机械换能器通道的功能工作和分子特性知之甚少。最近的研究表明，果蝇和脊椎动物听觉的机械换能器具有相同的门控机制，因此这种机制可以在果蝇耳朵的力学中进行非侵入性的探索。在这里，我们描述了该机制如何用于评估已鉴定蛋白质在机械感觉过程中的作用，特别是它们对机械转导的贡献。
The sensation of touch, gravity, and sound all rely on dedicated ion channels that transduce mechanical stimulus forces into electrical signals. The functional workings and molecular identities of these mechanotransducer channels are little understood. Recent work shows that the mechanotransducers for fly and vertebrate hearing share equivalent gating mechanisms, whereby this mechanism can be probed non-invasively in the mechanics of the Drosophila ear. Here, we describe how this mechanics can be used to evaluate the roles of identified proteins in the process of mechanosensation and, specifically, their contributions to mechanotransduction.