Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons
Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons
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DOI：
10.1097/00004872-200018040-00009
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发表时间：
2000-04-01
影响因子：
4.9
通讯作者：
Ferns, GA
中科院分区：
文献类型：
--
作者：
Fotherby, MD;Williams, JC;Ferns, GA
目的研究口服维生素C对动态血压和血脂的影响，设计一项为期6个月的双盲随机安慰剂对照交叉研究，交叉期之间有1周的洗脱期。方法40名年龄在60 ~ 80岁的男性和女性以交叉方式每天服用维生素C 500 mg或匹配的安慰剂，各3个月。门诊和24小时动态血压，血浆抗坏血酸和血脂测定在基线和结束时的每个交叉phase.Results门诊血压安慰剂和维生素C阶段之间没有变化。日间动态血压显示收缩压（2.0 +/- 5.2 mmHg; 95%置信区间0-3.9 mmHg）小幅但显著下降，但舒张压未下降。回归分析显示，随着基线日间血压的增加，补充维生素C后血压的下降幅度也增加。对高密度脂蛋白（HDL）胆固醇变化的回归分析显示，性别对HDL胆固醇变化有显著影响。在女性中，HDL胆固醇显著增加0.08 +/- 0.11 mmol/l，P = 0.007，但男性没有。治疗期间之间的低密度脂蛋白胆固醇没有变化。结论在老年人中，高摄入量的抗坏血酸对降低高收缩压有适度的影响，这可能有助于更高的维生素C摄入量和降低心血管疾病和中风的风险之间的关联。J Hypertens 2000，18：411-415（C）Lippincott威廉姆斯& Wilkins.
Objectives To determine the effect of oral vitamin C supplements on ambulatory blood pressure and plasma lipids.Design A 6-month doubts-blind randomized placebo-controlled cross-over study with a 1-week washout between cross-over periods.Methods Vitamin C 500 mg daily or matching placebo was given to 40 men and women aged between 60 and 80 years for 3 months each in a cross-over fashion, Clinic and 24-h ambulatory blood pressure, plasma ascorbate and lipids were measured at baseline and at the end of each cross-over phase.Results Clinic blood pressure did not change between placebo and Vitamin C phases. Daytime ambulatory blood pressure showed a small but significant fail in systolic blood pressure (2.0 +/- 5.2 mmHg; 95% confidence interval 0-3.9 mmHg) but not in diastolic blood pressure. Regression analysis showed that with increasing baseline daytime blood pressure the fall in blood pressure with vitamin C supplementation increased. Regression analysis of the change in high-density lipoprotein (HDL) cholesterol showed a significant effect of sex on the change in HDL cholesterol. In women, but not men, HDL cholesterol increased significantly by 0.08 +/- 0.11 mmol/l, P = 0.007. There was no change in low-density lipoprotein cholesterol between treatment periods.Conclusion In older adults high intakes of ascorbic acid have modest effects on lowering high systolic blood pressure, which could contribute to the reported association between higher vitamin C intake and lower risk of cardiovascular disease and stroke. J Hypertens 2000, 18:411-415 (C) Lippincott Williams & Wilkins.