On the possibility to detect lipid in atherosclerotic plaques using intravascular photoacoustic imaging.
On the possibility to detect lipid in atherosclerotic plaques using intravascular photoacoustic imaging.
复制标题
关于使用血管内光声成像检测动脉粥样硬化斑块中脂质的可能性。
DOI：
10.1109/iembs.2009.5334213
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Emelianov,Stanislav
中科院分区：
文献类型：
--
作者：
Wang,Bo;Su,Jimmy;Amirian,James;Litovsky,SilvioH;Smalling,Richard;Emelianov,Stanislav
大脂质核心常见于易破裂的动脉粥样硬化斑块中。检测动脉粥样硬化斑块中脂质的位置和分布，对于易损斑块的诊断和治疗有很大帮助。最近推出的血管内光声（IVPA）成像——一种对组织的光吸收特性进行成像的技术——可用于检测和区分动脉粥样硬化斑块。在这项工作中，我们进一步研究了使用光谱 IVPA 成像可视化动脉粥样硬化斑块中脂质的能力。 IVPA 成像是在 1200 – 1230 nm 波长范围内对离体兔主动脉进行的。在富含脂质的斑块中，该光谱范围内的光声信号强度的表现与脂肪组织的光学吸收光谱相似。为了区分脂质与其他类型的组织，使用了相关分析。具体来说，IVPA 信号与从多波长 IVPA 图像重建的脂质吸收光谱之间的类内相关性是在逐像素的基础上进行的。所得的相关图显示了动脉粥样硬化斑块中脂质的分布。通过组织的组织病理学分析进一步证实了脂质的分布。我们的研究结果表明，光谱 IVPA 成像与相关分析一起可用于检测动脉粥样硬化斑块中的脂质。
Large lipid core is common in rupture-prone atherosclerotic plaques. Detection of the location and distribution of lipid in the atherosclerotic plaques can greatly benefit the diagnosis and treatment of vulnerable plaques. Recently introduced intravascular photoacoustic (IVPA) imaging - a technique to image the optical absorption property of tissue - can be used to detect and differentiate atherosclerotic plaques. In this work, we further investigated the ability of using spectroscopic IVPA imaging to visualize the lipid in atherosclerotic plaques. IVPA imaging was performed on an ex-vivo rabbit aorta in the 1200 – 1230 nm wavelength range. In the lipid-rich plaques, the photoacoustic signal strength within this spectral range behaved similar to the optical absorption spectrum of fatty tissue. To distinguish lipid from other types of tissue, correlation analysis was used. Specifically, intraclass correlation between the IVPA signals and the absorption spectrum of lipid reconstructed from multi-wavelength IVPA images was conducted on a pixel-by-pixel basis. The resulted correlation map showed the distribution of lipid in the atherosclerotic plaques. The distribution of lipid is further confirmed by histopathological analysis of tissue. The results of our study suggest that spectroscopic IVPA imaging, together with correlation analysis, may be used to detect lipid in atherosclerotic plaques.