Clinical consequences of sensitisation in affective disorder: A case register study
Clinical consequences of sensitisation in affective disorder: A case register study
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DOI：
10.1016/s0165-0327(97)00128-6
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发表时间：
1998-01-01
影响因子：
6.6
通讯作者：
Bolwig, TG
中科院分区：
文献类型：
--
作者：
Kessing, LV;Mortensen, PB;Bolwig, TG
临床上对发作初始过程的测量可能反映了情感障碍的敏化过程。然而，这些措施的临床后果尚未得到研究。在一项病例登记研究中，研究了初始发作过程的测量与随后的酗酒、痴呆、死亡和自杀未遂/自杀风险的预测效果，该研究包括 1971 年至 1993 年丹麦所有入院的原发性情感障碍患者。分析中总共纳入了 8737 名患有不止一次发作的患者。疾病初次发作之间的时间间隔很短，反映出疾病的严重程度，预示着随后发生痴呆的风险会增加，而对于单相情感障碍患者来说，随后酗酒的风险会降低。令人惊讶的是，随着疾病初始发作间隔的逐渐缩短，渐进性病程并没有预测作用。同样，对初始发作过程的任何测量都无法证明对死亡或自杀行为风险的预测作用。 (C) 1998 Elsevier Science B.V.
Clinically derived measures of the initial course of episodes might reflect a process of sensitisation in affective disorder. However, the clinical consequences of such measures have not been investigated. The predictive effect of measures of the initial course of episodes was investigated in relation to the subsequent risk of alcoholism, dementia, death and suicidal attempts/suicide in a case register study including all hospital admissions with primary affective disorder in Denmark from 1971 to 1993. A total of 8737 patients with more than one episode were included in the analyses. A short period between initial episodes of the illness, reflecting a great intensity of illness, predicted increased risk of subsequent development of dementia, and for unipolar patients, decreased risk of subsequent alcoholism. Surprisingly, a progressive course, with decreasing intervals between initial episodes of the illness, had no predictive effect. Similarly, no predictive effects on the risk of death or suicidal acts could be demonstrated with any measure of the initial course of episodes. (C) 1998 Elsevier Science B.V.