Maps of Time to Maximum and Time to Peak for Mismatch Definition in Clinical Stroke Studies Validated With Positron Emission Tomography
Maps of Time to Maximum and Time to Peak for Mismatch Definition in Clinical Stroke Studies Validated With Positron Emission Tomography
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DOI：
10.1161/strokeaha.110.594432
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发表时间：
2010-12-01
期刊：
影响因子：
8.3
通讯作者：
Sobesky, Jan
中科院分区：
文献类型：
--
作者：
Zaro-Weber, Olivier;Moeller-Hartmann, Walter;Sobesky, Jan
背景和目的：灌注加权成像衍生的最大时间（Tmax）图越来越多地用于临床卒中研究中识别有风险的组织（例如，雷管和EPITHET）。使用定量正电子发射断层扫描（PET），我们评估了Tmax来定义中风患者的半影血流阈值，并将其性能与非反卷积时间到峰值（TTP）图进行了比较。方法：对急性脑卒中患者脑皮层感兴趣区灌注加权成像和定量15o水PET成像进行对比分析。接收机-工作特征曲线分析描述了Tmax（曲线下面积）的阈值独立性能，并确定了识别半影流的最佳阈值（等灵敏度和特异性阈值）(
Background and Purpose-Perfusion-weighted imaging-derived maps of time-to-maximum (Tmax) are increasingly used to identify the tissue at risk in clinical stroke studies (eg, DEFUSE and EPITHET). Using quantitative positron emission tomography (PET), we evaluated Tmax to define the penumbral flow threshold in stroke patients and compared its performance to nondeconvolved time-to-peak (TTP) maps.Methods-Comparative perfusion-weighted imaging and quantitative 15O-water PET images of acute stroke patients were analyzed using cortical regions of interest. A receiver-operating characteristic curve analysis described the threshold independent performance of Tmax (area under the curve) and identified the best threshold (equal sensitivity and specificity threshold) to identify penumbral flow (