Epithelial modulation of tracheal smooth muscle response to antigenic stimulation.
Epithelial modulation of tracheal smooth muscle response to antigenic stimulation.
复制标题
上皮调节气管平滑肌对抗原刺激的反应。
DOI：
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发表时间：
1986
影响因子：
3.3
通讯作者：
F. Muller
中科院分区：
文献类型：
--
作者：
N. Frossard;F. Muller
研究了上皮细胞在大鼠气管收缩反应中的作用。所观察到的不同调制进行了讨论迷走神经成分的上皮层。大鼠气管对免疫刺激的反应依赖于上皮细胞的存在，上皮细胞的存在延缓了松弛阶段而不影响收缩。这种延长被新生儿辣椒素预处理废除，而P物质诱导一个显着更大的松弛比deepithelialized气管的预收缩的完整。5-羟色胺浓度-反应曲线在完整的制剂中向右移动，新生儿辣椒素预处理可部分逆转，但组织存在低反应性。假设上皮细胞释放的松弛因子，可能依赖于P物质能神经支配。毒蕈碱胆碱能神经支配轻微调制的收缩，但不是在抗原诱导的反应的松弛，独立的存在下的上皮层。4-氨基吡啶诱导上皮依赖性增强收缩抗原和血清素，这涉及乙酰胆碱在一个步骤的反应级联。因此，在大鼠气管上皮依赖的收缩和舒张因子。
The role of the epithelium has been studied in the contractile responses of rat trachea. The different modulations observed are discussed in respect to vagal components of the epithelial layer. Responses of rat trachea to immunologic stimulation are shown to be dependent on the presence of the epithelium, which prolongs the relaxation stage without affecting the contractions. This prolongation is abolished by neonatal capsaicin pretreatment, whereas substance P induces a significantly greater relaxation of serotonin-precontracted intact than deepithelialized trachea. Serotonin concentration-response curves are shifted to the right in intact preparations, which is partly reversed by neonatal capsaicin pretreatment, but a hyporeactivity of the tissue exists. A relaxing factor released by the epithelium is hypothesized, possibly dependent on substance P-ergic innervation. Muscarinic cholinergic innervation slightly modulates the contractions but not the relaxations in antigen-induced responses, independently on the presence of the epithelial layer. 4-Aminopyridine induces epithelium-dependent potentiations of contractions to antigen and to serotonin, which involves acetylcholine at one step of the reaction cascade. Epithelial-dependent contracting and relaxing factors are thus suggested in rat trachea.