Importance of Cholera and Other Etiologies of Acute Diarrhea in Post-Earthquake Port-au-Prince, Haiti
Importance of Cholera and Other Etiologies of Acute Diarrhea in Post-Earthquake Port-au-Prince, Haiti
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DOI：
10.4269/ajtmh.13-0514
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发表时间：
2014-03-01
影响因子：
3.3
通讯作者：
Pape, Jean W.
中科院分区：
文献类型：
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作者：
Charles, Macarthur;Delva, Glavdia G.;Pape, Jean W.
我们估计了在两个城市卫生机构（霍乱治疗中心（CTC）和口服补液点（ORP））的患者在雨季和旱季期间因霍乱和其他病原体引起的腹泻比例。在2011年4月1日至2012年11月30日期间，从10，845名来GHESKIO CTC或社区ORP的急性腹泻患者中的1，206名患者中收集粪便样本，培养霍乱弧菌，并通过多重聚合酶反应进行检测。从CTC的979份标本中的409份（41.8%，95%置信区间[CI] = 38.7-44.9%）和ORP的227份标本中的45份（19.8%，95% CI = 14.8-25.6%）中分离出霍乱弧菌。频率从旱季的21.4%（95%CI = 16.6-26.7%）到雨季的46.8%（95%CI = 42.9-50.7%）不等。志贺氏菌、肠致病性大肠杆菌、轮状病毒和隐孢子虫是5岁以下儿童腹泻的常见原因。
We estimated the proportion of diarrhea attributable to cholera and other pathogens during the rainy and dry seasons in patients seen in two urban health settings: a cholera treatment center (CTC) and oral rehydration points (ORPs). During April 1, 2011-November 30, 2012, stool samples were collected from 1,206 of 10,845 patients who came to the GHESKIO CTC or to the community ORPs with acute diarrhea, cultured for Vibrio cholerae, and tested by multiplex polymerase reaction. Vibrio cholerae was isolated from 409 (41.8%, 95% confidence interval [CI] = 38.7-44.9%) of the 979 specimens from the CTC and in 45 (19.8%, 95% CI = 14.8-25.6%) of the 227 specimens from the ORPs. Frequencies varied from 21.4% (95% CI = 16.6-26.7%) during the dry season to 46.8% (95% CI = 42.9-50.7%) in the rainy season. Shigella, enterotoxigenic Escherichia coli, rotavirus, and Cryptosporidium were frequent causes of diarrhea in children less than five years of age.