Effects of infusion of cholinergic drugs into the prefrontal cortex area on delayed matching to position performance in the rat
Effects of infusion of cholinergic drugs into the prefrontal cortex area on delayed matching to position performance in the rat
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DOI：
10.1016/0006-8993(95)01404-7
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发表时间：
1996-03-04
期刊：
影响因子：
2.9
通讯作者：
Slangen, JL
中科院分区：
文献类型：
--
作者：
Herremans, AHJ;Hijzen, TH;Slangen, JL
接受延迟匹配位置（DMTP）任务训练的老鼠在解决任务的延迟期间表现出中介行为。将胆碱能拮抗剂东莨菪碱输注到内侧前额皮质区（mPFC），会出现剂量依赖性的表现受损，与延迟无关。这些结果表明东莨菪碱不会特别影响工作记忆。输注胆碱酯酶抑制剂毒扁豆碱、毒蕈碱亚型受体拮抗剂、多巴胺 (D-1) 拮抗剂 SCH23390 和 GABA-A 受体拮抗剂荷包牡丹碱，不会影响 DMTP 任务的表现，事后分析发现东莨菪碱仅在大多数试验中使用中介行为的动物中以延迟依赖性方式损害辨别能力。此外，时间采样方法表明，将东莨菪碱注入 mPFC 会扰乱任务期间的中介行为。结果表明，mPFC 中的胆碱能系统在引导注意力到任务相关行为方面发挥着作用。
Rats trained on a Delayed Matching To Position (DMTP) task displayed mediating behavior during delays to solve the task. Infusion of the cholinergic antagonist,scopolamine into the medial Prefrontal Cortex area (mPFC), dose dependently impaired performance independent of delay. These results indicate that scopolamine does not specifically affect working memory. Infusion of the cholinesterase inhibitor physostigmine, muscarinic subtype receptor antagonists, the dopamine (D-1) antagonist SCH23390, and of the GABA-A receptor antagonist bicuculline, did not affect performance in the DMTP task, in a post-hoc analysis scopolamine was found to impair discriminability in a delay-dependent manner only in animals that used mediating behavior in the majority of the trials. Furthermore, a time sampling method indicated that scopolamine infusions into the mPFC disrupted mediating behavior during the task. Results suggest that cholinergic systems in the mPFC play a role in directing attention to task relevant behavior.