The role of residence near hazardous waste sites containing benzene in the development of hematologic cancers in upstate New York
The role of residence near hazardous waste sites containing benzene in the development of hematologic cancers in upstate New York
复制标题
DOI：
10.2478/s13382-011-0037-8
复制
发表时间：
2011-01-01
影响因子：
2
通讯作者：
Carpenter, David O.
中科院分区：
文献类型：
--
作者：
Boberg, Erik;Lessner, Lawrence;Carpenter, David O.
流行病学研究表明，苯的环境暴露与血液系统癌症之间存在关联，但这种关系尚未确定。本研究的目的是评估居住在含苯危险废物场所附近与血液系统癌症患者出院率之间的潜在关联。我们确定了1993年至2008年纽约州（除纽约市外）血液系统癌症患者的出院人数。使用描述性统计和负二项回归模型对出院率进行比较在调整潜在的混杂因素后，我们发现慢性淋巴细胞白血病（CLL）的住院率增加了15%[率比（RR）：1.15; 95%置信区间（CI）：苯暴露部位的总白血病出院率增加22%（RR：1.22; 95% CI：1.04-1.43），总淋巴瘤出院率增加17%（RR：1.17; 95% CI：1.02-1.35）。我们发现，与高加索人相比，非洲裔美国人暴露的影响更大，女性与男性相比，社会经济地位（SES）较高的人与社会经济地位较低的人相比，对几种研究疾病的影响更大。在控制了主要混杂因素后，我们发现，居住在含有苯废物的邮政编码区的人，几种血液系统癌症的出院率在统计学上显著增加。这些结果提供了额外的支持环境暴露于苯和血液系统癌症的风险之间的关系。
Epidemiologic studies suggest an association between environmental exposure to benzene and hematologic cancers, but the relationship is not firmly established. The aim of this study was to assess the potential association between residence near hazardous waste sites containing benzene and hospitalization discharge rates for persons having hematologic cancers.We determined the number of hospital discharges of people with hematologic cancers in New York State except for New York City for the years 1993 to 2008.Descriptive statistics and negative binomial regression models were used to compare the rates of hospitalization of residents in zip codes containing hazardous waste sites containing benzene to the rates of discharges from residents in zip codes without waste sites.When adjusting for potential confounders we found a 15% increase in the rate of hospitalization for chronic lymphatic leukemia (CLL) [rate ratio (RR): 1.15; 95% confidence interval (CI): 1.00-1.33], a 22% increase in the rate of discharges for total leukemia (RR: 1.22; 95% CI: 1.04-1.43) and a 17% increase in the rate of discharges for total lymphoma (RR: 1.17; 95% CI: 1.02-1.35) in the benzene exposed sites. We found greater effects of exposure in African Americans compared to Caucasians, females compared to males and people with higher socioeconomic status (SES) compared to those with lower SES for several of the diseases studied.After controlling for major confounders we found statistically significant increases in discharge rates for several hematologic cancers in persons residing in zip codes containing benzene waste sites. These results provide additional support for a relationship between environmental exposure to benzene and risk of hematologic cancers.