A prospective study of trans-fatty acid levels in blood and risk of prostate cancer
A prospective study of trans-fatty acid levels in blood and risk of prostate cancer
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DOI：
10.1158/1055-9965.epi-07-0673
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发表时间：
2008-01-01
影响因子：
3.8
通讯作者：
Ma, Jing
中科院分区：
文献类型：
--
作者：
Chavarro, Jorge E.;Stampfer, Meir J.;Ma, Jing
背景：先前的研究表明反式脂肪酸摄入量与前列腺癌之间存在正相关。因此，我们前瞻性地评估了血液反式脂肪酸水平和前列腺癌的风险之间的关联。方法：我们进行了巢式病例对照研究，14,916名表面健康的男性谁在1982年提供的血液样本。在13年的随访中，对476名诊断为前列腺癌的男性及其匹配的对照组进行了血液脂肪酸水平测定。对照组根据基线时的年龄和吸烟状况与病例进行个体匹配。条件Logistic回归被用来估计的相对风险和95%置信区间的总，非侵略性（阶段A/B和低级别），和侵略性（阶段C/D，高级别，随后的远处转移或死亡）前列腺癌与特定的trans-fatty acids.Results的血液水平：所有的反式脂肪酸检查的血液水平是无关的总前列腺癌的风险。当根据肿瘤的侵袭性对结果进行划分时，血液中18：1 n-9 t水平、所有18：2 t检测和总反式脂肪酸与非侵袭性肿瘤呈正相关。18：1 n-9 t组的反式脂肪酸水平与最低五分位数组相比的相对风险（95%置信区间; P趋势）为2.16（1.12-4.17，0.11），18：2 t组为1.97（1.03-3.75; 0.01），总反式脂肪酸组为2.21（1.14-4.29; 0.06）。没有反式脂肪检查与侵略性prostate tumors.Conclusion：反式异构体的油酸和亚油酸的血液水平与非侵略性前列腺肿瘤的风险增加。由于这种类型的肿瘤代表了使用前列腺特异性抗原筛查检测到的前列腺癌的很大比例，这些发现可能对预防前列腺癌有意义。
Background: Previous studies suggest a positive association between markers of trans-fatty acid intake and prostate cancer. We therefore prospectively evaluated the association between blood trans-fatty acid levels and risk of prostate cancer.Methods: We conducted a nested case-control study among 14,916 apparently healthy men who provided blood samples in 1982. Blood fatty acid levels were determined for 476 men diagnosed with prostate cancer during a 13-year follow-up and their matched controls. Controls were individually matched to cases according to age and smoking status at baseline. Conditional logistic regression was used to estimate the relative risk and 95% confidence interval of total, nonaggressive (stage A/B and low grade), and aggressive (stage C/D, high grade, subsequent distant metastasis or death) prostate cancer associated with blood levels of specific trans-fatty acids.Results: Blood levels of all the trans-fatty acids examined were unrelated to total prostate cancer risk. When results were divided according to tumor aggressiveness, blood levels of 18:1n-9t, all the 18:2t examined, and total trans-fatty acids were positively associated to nonaggressive tumors. The relative risks (95% confidence intervals; P trend) comparing top with bottom quintile trans-fatty acid levels were 2.16 (1.12-4.17, 0.11) for 18:1n-9t, 1.97 (1.03-3.75; 0.01) for total 18:2t, and 2.21 (1.14-4.29; 0.06) for total trans-fatty acids. None of the trans fats examined was associated with aggressive prostate tumors.Conclusion: Blood levels of trans isomers of oleic and linoleic acids are associated with an increased risk of nonaggressive prostate tumors. As this type of tumors represents a large proportion of prostate cancer detected using prostate-specific antigen screening, these findings may have implications for the prevention of prostate cancer.