Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice
Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice
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DOI：
10.1007/s10787-022-01007-w
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发表时间：
2022-07-06
影响因子：
5.8
通讯作者：
Zhang, Lanyue
中科院分区：
文献类型：
--
作者：
Li, Chunlian;Zhang, Weicheng;Zhang, Lanyue
姜黄是药食同源的传统中药材之一。芳香姜黄酮是姜黄精油的主要成分。本研究的目的是探讨芳香姜黄酮对 DSS 性结肠炎的治疗及其对肠道菌群紊乱的调节作用。补充不同浓度芳香姜黄酮和美沙拉秦的雄性KM小鼠在饮用水中加入2% DSS以诱导结肠炎。收集结肠和盲肠内容物用于结肠炎病变评估和炎症相关基因分析，并收集结肠内容物用于肠道微生物群。结果表明，芳香姜黄酮治疗可显着防止结肠缩短，减轻结肠组织的损伤，并减少结肠炎症细胞因子TNF-α和COX-2。此外，16S rDNA基因序列数据表明，芳香姜黄酮提高了细菌物种的丰度，保留了一些有益细菌，并减少了有害细菌。芳香姜黄酮下调结肠炎症细胞因子并调节肠道菌群丰度，有助于改善 DSS 诱导的结肠炎。定期摄入食用草药可能有助于预防溃疡性结肠炎相关疾病。
Curcuma longa L. is one of the traditional Chinese herbs in the list of medicinal and food homology. Aromatic-turmerone is the main ingredient in turmeric essential oil. The aim of the present study is to investigate the treatment of Aromatic-turmerone on DSS-included colitis and its regulatory effect on intestinal flora disorder. Male KM mice supplemented with different concentration of aromatic-turmerone and mesalazine are subjected to 2% DSS in drinking water to induce colitis. Colon and cecum contents were collected for colitis lesion evaluation and inflammation-related gene analysis and colon contents for gut microbiota. The results show that treatments with Aromatic-turmerone significantly prevents colon shortening, alleviates the damage of colonic tissue, and reduces colonic inflammatory cytokines TNF-alpha and COX-2. Furthermore, the 16S rDNA gene sequence data indicate that Aromatic-turmerone improve the abundance of bacterial species, maintain some beneficial bacteria, and reduce harmful bacteria. Aromatic-turmerone downregulates the colonic inflammatory cytokines and modulates the abundance of intestinal flora, which is conductive to ameliorates DSS-induced colitis. Regularly intake of the edible herb may be help to prevent ulcerative colitis-related diseases.