Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population
Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population
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DOI：
10.3945/ajcn.115.117614
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发表时间：
2015-11-01
影响因子：
7.1
通讯作者：
Lee, Yung Seng
中科院分区：
文献类型：
--
作者：
Aris, Izzuddin M.;Soh, Shu E.;Lee, Yung Seng
背景：母亲肥胖和高血糖会增加后代日后肥胖和糖尿病的风险。目的：我们在亚洲母子队列中研究孕前体重指数(PpBMI)与后代生长的关系。设计：孕妇在怀孕26-28周时进行75g 2小时口服葡萄糖耐量试验。937名独生子女，=3个月龄。相反，母亲的ppBMI与出生变量以及出生前36个月体重和BMI的条件增长呈正相关。然而，孕期空腹血糖和孕前肥胖状况与出生后36个月的后代生长和超重状况显著相关(P-交互作用<；0.01)。在非肥胖母亲中，孕期空腹血糖每增加一个单位就会增加子代体重(B：0.08；95%CI：0.008，0.16；P=0.03)和体重指数(B：0.08；95%CI：0.003，0.15；P=0.04)，并增加出生后36个月超重的风险(OR：1.36；95%CI：1.10，1.68)。然而，在肥胖母亲中，孕期空腹血糖每单位增加与出生前36个月的子女体重下降(B：-0.01；95%CI：-0.02，-0.003)、体重指数(B：-0.008；95%CI：-0.01，-0.002)和超重风险降低(OR：0.59；95%CI：0.41，0.86)相关。虽然合并分析显示在3个月龄时没有明显差异，但在非肥胖母亲和肥胖母亲的子女出生后36个月内，妊娠期血糖与体重和BMI分别存在对比和相反的关联。
Background: Maternal obesity and hyperglycemia increase risk of obesity and diabetes in offspring later in life.Objective: We examined the relation between gestational glycemia and prepregnancy body mass index (ppBMI) with offspring growth in an Asian mother-offspring cohort.Design: Pregnant mothers undertook a 75-g 2-h oral-glucose-tolerance test at 26-28 wk of gestation. In 937 singleton offspring, = 3 mo of age. In contrast, maternal ppBMI was positively associated with birth variables and conditional growth in weight and BMI in the first 36 mo of life. However, gestational FPG and prepregnancy obesity status interacted significantly for the association with offspring growth and overweight status in the first 36 mo of life (P-interaction < 0.01). In nonobese mothers, each unit increase in gestational FPG was associated with increased offspring weight (B: 0.08; 95% CI: 0.008, 0.16; P = 0.03) and BMI (B: 0.08; 95% Cl: 0.003, 0.15; P = 0.04) as well as increased risk of overweight in the first 36 mo of life (OR: 1.36; 95% CI: 1.10, 1.68). However, in obese mothers, each unit increase in gestational FPG was associated with decreased offspring weight (B: -0.01; 95% CI: -0.02, -0.003) and BMI (B: -0.008; 95% CI: -0.01, -0.002) velocity (P < 0.01 for both) and decreased risk of overweight (OR: 0.59; 95% CI: 0.41, 0.86) in the first 36 mo of life.Conclusions: Prepregnancy adiposity was associated with offspring growth in early childhood. Although pooled analyses showed no demonstrable difference by 3 mo of age, there were contrasting and opposite associations of gestational glycemia with weight and BMI in the first 36 mo of life in offspring of nonobese and obese mothers separately.