Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels
Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels
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DOI：
10.1248/bpb.21.1277
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发表时间：
1998-12-01
影响因子：
2
通讯作者：
Komatsu, Y
中科院分区：
文献类型：
--
作者：
Kase, Y;Saitoh, K;Komatsu, Y
为了确定Hange-shashin-to（TJ-14）降低前列腺素E2（PGE 2）水平的机制，在体内检查了对血液皮质酮水平的影响，并在体外评估了对环氧合酶（考克斯）活性的影响，以125至1000 mg/kg的剂量水平经口给予大鼠TJ-14，导致血液皮质酮水平的剂量依赖性增加。TJ-14的成分人参和人参也参与血皮质酮的增加。TJ-14即使在1000 μ g/ml的剂量下也不抑制考克斯-1的活性，而在10和1000 μ g/ml之间的剂量水平下抑制考克斯-2。提示TJ-14降低考克斯-2的作用部分是通过皮质酮和考克斯-2的抑制而实现的。
To determine the mechanisms by which Hange-shashin-to (TJ-14) reduces prostaglandin E2 (PGE2) levels, the effects on blood corticosterone levels were examined in vivo and the effects on cyclooxygenase (COX) activity in vitro assessed, TJ-14, orally administered to rats at dose levels between 125 and 1000 mg/kg, caused a dose-dependent increase in blood corticosterone levels. We also showed that Glycyrrhizae Radix and Ginseng Radix, constituents of TJ-14, are involved in the increase in blood corticosterone, The activity of COX-1 was not inhibited by TJ-14 even at a dose of 1000 mu g/ml, while COX-2 was inhibited at dose levels between 10 and 1000 mu g/ml. The constituents Scutellariae Radix, Glycyrrhizae Radix and Coptidis Rhizoma were believed to be involved in COX-2 inhibition.These results suggest that the effect of TJ-14 in decreasing PGE2 is partially mediated by corticosterone and inhibition of COX-2.