RISK ASSESSMENT OF AMNIOCENTESIS BETWEEN 11 AND 15 WEEKS - COMPARISON TO LATER AMINOCENTESIS CONTROLS
RISK ASSESSMENT OF AMNIOCENTESIS BETWEEN 11 AND 15 WEEKS - COMPARISON TO LATER AMINOCENTESIS CONTROLS
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DOI：
10.1002/pd.1970141004
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发表时间：
1994-10-01
影响因子：
3
通讯作者：
TABSH, K
中科院分区：
文献类型：
--
作者：
CRANDALL, BF;KULCH, P;TABSH, K
我们研究了693个连续的早期羊膜腔(15周前)，发现28周的自然流产率为1.5%。接受标准羊膜穿刺术(15-20周)的对照组妇女在同一时期经历了0.6%的胎儿损失。两组之间没有其他明显的差异。早期羊膜穿刺术结果一般在标准羊膜穿刺术前4-6周和绒毛取样(CVS)后1-3周得到。甲胎蛋白(AFP)可以在11到15周的羊水样本中准确地检测出来，但还需要进一步的研究来确定神经管缺陷(NTD)检测的准确性。包括本研究在内，已有超过5800例早期羊膜腔出血的报告，结果表明，这是一种相对安全的产前诊断测试，是CVS和后来的羊膜穿刺术的替代方法。
We studied 693 consecutive early amniocenteses (prior to 15 weeks) and found a spontaneous abortion rate to 28 weeks' gestation of 1.5 per cent. A control group of women having standard amniocentesis (15-20 weeks) experienced a 0.6 per cent fetal loss in the same period. There were no other apparent differences between the two groups. Early amniocentesis results are generally available 4-6 weeks before standard amniocentesis and 1-3 weeks after chorionic villus sampling (CVS). Alpha-fetoprotein (AFP) can be accurately assayed in 11- to 15-week amniotic fluid samples but additional studies are necessary to determine the accuracy of neural tube defect (NTD) detection. Including the present study, over 5800 early amniocenteses have been reported and the results suggest that this is a relatively safe prenatal diagnostic test and an alternative to CVS and later amniocentesis.