2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines: Recent Advances and Future Challenges
2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines: Recent Advances and Future Challenges
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DOI：
10.1002/adhm.202001743
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发表时间：
2021-01
影响因子：
10
通讯作者：
Yuanyuan Zheng;Xiangqian Hong;Jiantao Wang;Longbao Feng;Taojian Fan;R. Guo;Han Zhang
中科院分区：
文献类型：
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作者：
Yuanyuan Zheng;Xiangqian Hong;Jiantao Wang;Longbao Feng;Taojian Fan;R. Guo;Han Zhang
再生医学已成为医学科学中最热门的研究课题之一，为修复人体组织缺损提供了一种有前途的方法。由于其优异的物理化学性质，二维纳米材料在再生医学中的应用逐渐发展，近年来吸引了广泛的研究兴趣。特别是，石墨烯及其衍生物、黑磷和过渡金属二硫属化物应用于组织工程的所有方面，以替代或修复组织。本文综述了基于2D纳米材料的水凝胶、纳米片或支架应用的最新进展，这些材料被设计用于修复皮肤、骨和软骨组织。还提供了对其他应用的评论，包括心肌再生，骨骼肌修复，神经再生，脑疾病治疗和脊髓愈合。讨论了二维纳米材料在再生医学中应用的挑战和前景。
Regenerative medicine has become one of the hottest research topics in medical science that provides a promising way for repairing tissue defects in the human body. Due to their excellent physicochemical properties, the application of 2D nanomaterials in regenerative medicine has gradually developed and has been attracting a wide range of research interests in recent years. In particular, graphene and its derivatives, black phosphorus, and transition metal dichalcogenides are applied in all the aspects of tissue engineering to replace or restore tissues. This review focuses on the latest advances in the application of 2D‐nanomaterial‐based hydrogels, nanosheets, or scaffolds that are engineered to repair skin, bone, and cartilage tissues. Reviews on other applications, including cardiac muscle regeneration, skeletal muscle repair, nerve regeneration, brain disease treatment, and spinal cord healing are also provided. The challenges and prospects of applications of 2D nanomaterials in regenerative medicine are discussed.