Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings
Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings
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DOI：
10.1246/bcsj.81.278
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发表时间：
2008-02-15
影响因子：
4
通讯作者：
Sajiki, Hironao
中科院分区：
文献类型：
--
作者：
Ito, Nobuhiro;Esaki, Hiroyoshi;Sajiki, Hironao
建立了一种适用于芳香环的铂/C-D2O-H-2体系的氢代反应方法。尤其是苯酚，即使在室温下也能进行完全的氢化，在温和的条件下，其他富含电子的芳香族原子核也能有效地氢化。报道了存在法的适用范围和局限性，以及它在合成用于实际多克尺度合成的氚标记生物活性化合物和氚标记积木方面的应用。
An effective and applicable deuteration method for aromatic rings using Pt/C-D2O-H-2 system was established. Especially, phenol was fully deuterated even at room temperature, and other electron-rich aromatic nuclei were efficiently deuterated under mild conditions. The scope and limitations of the presence method and its application to the synthesis of deuterium-labeled biologically active compounds and deuterium-labeled building blocks for practical multi-gram scale syntheses are reported.