Reward-related neuronal activity in the subthalamic nucleus of the monkey
Reward-related neuronal activity in the subthalamic nucleus of the monkey
复制标题
DOI：
10.1097/00001756-200508010-00022
复制
发表时间：
2005-08-01
期刊：
影响因子：
1.7
通讯作者：
Apicella, P
中科院分区：
文献类型：
--
作者：
Darbaky, Y;Baunez, C;Apicella, P
丘脑底核是基底神经节中运动信息处理的关键结构。人们对它参与行为的其他方面（例如动机）知之甚少。我们研究了在丘脑底核的神经元活动，而猴子进行手臂达到运动，以获得液体奖励。大多数神经元在任务的运动和奖励阶段都受到调制。在奖励发放之后或之前发生的活动变化包括放电的增加或减少，与嘴部运动没有直接关系。这些发现表明，大脑皮层神经元参与了奖赏的检测和期望，这与这些神经元在处理动机信息中的作用一致。
The subthalamic nucleus is a key structure for motor information processing in the basal ganglia. Little is known about its involvement in other aspects of behavior such as motivation. We investigated neuronal activity in the subthalamic nucleus while a monkey performed arm-reaching movements to obtain a liquid reward. Most neurons were modulated both during the movement and reward phases of the task. The changes in activity occurring after or just before the delivery of reward consisted of either increases or decreases in firing and were not directly related to mouth movements. These findings indicate that STN neurons are involved in the detection and expectation of reward, consistent with a role for these neurons in the processing of motivational information.