Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
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DOI：
10.1038/75753
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发表时间：
2000-06-01
影响因子：
25
通讯作者：
Gao, WQ
中科院分区：
文献类型：
--
作者：
Zheng, JL;Gao, WQ
对于哺乳动物的耳蜗毛细胞，命运的决定通常是通过出生来完成的。我们在这里报道，在出生后的大鼠耳蜗外植体培养中，果蝇基因无性系的小鼠同源基因Math1的过度表达导致了额外的毛细胞。令人惊讶的是，我们发现异位毛细胞的来源是位于大上皮脊感觉上皮外的柱状上皮细胞，这通常会产生内沟细胞。此外，Math1的表达也促进了出生后椭圆形支持细胞向毛细胞的转化。因此，Math1足以在耳朵中产生毛细胞，而未成熟的哺乳动物内耳保留了产生新毛细胞的能力。
For mammalian cochlear hair cells, fate determination is normally completed by birth. We report here that overexpression of Math1, a mouse homolog of the Drosophila gene atonal, in postnatal rat cochlear explant cultures resulted in extra hair cells. Surprisingly, we found that the source of the ectopic hair cells was columnar epithelial cells located outside the sensory epithelium in the greater epithelial ridge, which normally give rise to inner sulcus cells. Moreover, Math1 expression also facilitated conversion of postnatal utricular supporting cells into hair cells. Thus Math1 was sufficient for the production of hair cells in the ear, and immature postnatal mammalian inner ears retained the competence to generate new hair cells.