Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.
Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.
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DOI：
10.1016/j.tips.2015.09.003
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发表时间：
2016-01
影响因子：
13.8
通讯作者：
Drummond GS
中科院分区：
文献类型：
--
作者：
Abraham NG;Junge JM;Drummond GS
肥胖的全球流行与糖尿病和代谢综合征的后遗症继续有增无减。这一综述反映了血红素加氧酶(HO)-1/HO-2、胆绿素还原酶和HO活性升高在血管疾病中的作用的研究急剧增加。HO系统与其他系统一起减轻氧化应激对肥胖和心血管疾病（CVD）的有害影响。最近的报道表明，HO-1/HO-2蛋白表达和HO活性在代谢综合征相关的止血和ros依赖性扰动中具有几个重要作用。HO-1通过降解促氧化血红素和产生一氧化碳和胆红素来保护肥胖炎症应激中的组织，这两种物质都具有抗炎和抗凋亡的特性。相反，HO-1的抑制与细胞血红素和炎症状况（包括高血压、中风和动脉粥样硬化）的增加有关。HO-1是开发潜在治疗策略以逆转肥胖和代谢综合征临床并发症的主要焦点。
The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome. This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease. The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and cardiovascular disease (CVD). Recent reports indicate that HO-1/HO-2 protein expression and HO activity have several important roles in hemostasis and ROS-dependent perturbations associated with metabolic syndrome. HO-1 protects tissue during inflammatory stress in obesity through the degradation of pro-oxidant heme and the production of carbon monoxide (CO) and bilirubin, both of which have anti-inflammatory and anti-apoptotic properties. In contrast, repression of HO-1 is associated with increases of cellular heme and inflammatory conditions including hypertension, stroke and atherosclerosis. HO-1 is a major focus in the development of potential therapeutic strategies to reverse the clinical complications of obesity and metabolic syndrome.