Interictal interleukin-17A levels are elevated and correlate with seizure severity of epilepsy patients
Interictal interleukin-17A levels are elevated and correlate with seizure severity of epilepsy patients
复制标题
发作间期白细胞介素 17A 水平升高，且与癫痫患者的癫痫发作严重程度相关。
DOI：
10.1111/epi.12337
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发表时间：
2013-09-01
期刊：
影响因子：
5.6
通讯作者：
Wang, Xin
中科院分区：
文献类型：
--
作者：
Mao, Ling-Yan;Ding, Jing;Wang, Xin
白细胞介素17 A（IL-17 A）参与多种神经免疫性疾病的发病机制。我们的目的是评估IL-17 A与癫痫患者癫痫发作严重程度的关系。70例可能有症状的癫痫患者和68名健康对照者被纳入。测量发作间期血清IL-17 A和相关细胞因子（IL-23、IL-6、IL-1 β、干扰素γ（IFN-γ）和IL-10）水平。采用斯皮尔曼相关和多元线性回归分析癫痫发作严重程度与细胞因子浓度的关系。在另外30例癫痫患者（发作后或发作间期）和15例特发性炎性脱髓鞘疾病（IIDDs）患者中检测脑脊液（CSF）中的IL-17 A水平。与对照组相比，癫痫患者发作间期血清IL-17 A水平显著升高。IL-6、IFN-c和IL-1b水平也显著升高。斯皮尔曼相关性分析显示，IL-17 A、IL-6水平与退伍军人管理局癫痫发作频率和严重程度评定量表评分（VA评分）; IFN-γ、IL-10水平和国家医院癫痫发作严重程度量表（NHS 3）评分之间正相关。此外，IL-17 A水平与癫痫发作频率显著相关。多元线性回归检验显示，仅IL-17 A水平与VA评分独立正相关（B = 0.288，p = 0.027）。与发作间期患者和IIDDs患者相比，发作后CSF中的IL-17 A水平显著升高。我们的研究结果表明，发作间期IL-17 A水平与癫痫发作的严重程度高度相关。
Interleukin 17A (IL-17A) is implicated in the pathogenesis of several neuroimmunologic diseases. We aimed to evaluate the relationship between IL-17A and seizure severity in patients with epilepsy. Seventy patients with probable symptomatic epilepsy and 68 healthy controls were included. Interictal serum IL-17A and related cytokine (IL-23, IL-6, IL-1 beta, interferon gamma (IFN-gamma), and IL-10) levels were measured. The relationship between seizure severity and cytokine concentrations was assessed by Spearman correlation and multivariate linear regression test. IL-17A levels in the cerebrospinal fluid (CSF) were tested in 30 additional patients with epilepsy, either in the postictal or interictal period and 15 patients with idiopathic inflammatory demyelinating diseases (IIDDs). Interictal serum IL-17A levels were significantly elevated in patients with epilepsy compared to controls. IL-6, IFN-c, and IL-1b levels were also markedly elevated. Spearman correlation analysis revealed positive correlation between IL-17A, IL-6 levels and Veterans Administration Seizures Frequency and Severity Rating Scale score (VA score); IFN-gamma, IL-10 levels, and National Hospital Seizure Severity Scale (NHS3) score. In addition, IL-17A levels correlated significantly with seizure frequency. Multivariate linear regression test showed that only IL-17A levels were independently positively correlated with VA scores (B = 0.288, p = 0.027). Postictal IL-17A levels in the CSF were significantly elevated compared to interictal patients and patients with IIDDs. Our results suggest that interictal IL-17A levels correlated highly with seizure severity.