Antidiabetic Effects of a Standardized Egyptian Rice Bran Extract
Antidiabetic Effects of a Standardized Egyptian Rice Bran Extract
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DOI：
10.1002/ptr.4705
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发表时间：
2013-02-01
影响因子：
7.2
通讯作者：
Verspohl, Eugen J.
中科院分区：
文献类型：
--
作者：
Kaup, Rebecca M.;Khayyal, Mohamed T.;Verspohl, Eugen J.
从埃及稳定的米糠制备提取物，并将其标准化为除了其其他生物活性物质的含量之外还含有2% -谷维素，特别是生育三烯酚和多廿烷醇。标准化的提取物被发现具有浓度依赖性的影响，胰岛素释放在体外，这，但是，是不是介导的-生育三烯酚米糠（HPLC检测），因为可以预期的。廿烷醇和谷维素具有促胰岛素作用。通过使用葡萄糖耐量试验（血浆胰岛素增加），米糠的体外数据直接转化为大鼠的体内数据。生育三烯酚因其对肿瘤细胞的凋亡作用而众所周知;然而，尝试研究HEP-G2细胞中的葡萄糖摄取，其需要通过TNF-α诱导胰岛素抵抗状态。埃及米糠提取物具有抗糖尿病作用。- 谷维素是促胰岛素化合物阿魏酸的可能前体，是这种作用的候选物。因此，可以合理地假设糖尿病的患病率或至少糖尿病前期（2型）的情况可以通过研究的米糠提取物得到改善。提取物作为营养品的潜在用途目前正在进行更彻底的调查。版权所有（c）2012约翰威利父子有限公司
An extract was prepared from Egyptian stabilized rice bran and standardized to contain 2% -oryzanol in addition to its content of other bioactives, notably tocotrienol and policosanol. The standardized extract was found to have a concentration-dependent effect on insulin release in vitro, which, however, is not mediated by -tocotrienol in rice bran (detected by HPLC) as could have been expected. Policosanol and -oryzanol have insulinotropic effects. The in vitro data of rice bran directly translate into in vivo data of rats by using a glucose tolerance test (increase in plasma insulin). Tocotrienols are well known for their apoptotic effect on tumor cells; nevertheless, an attempt was made to study glucose uptake in HEP-G2 cells, which needs to induce an insulin-resistant state by TNF-. The Egyptian rice bran extract has an antidiabetic effect. -Oryzanol, which is a possible precursor of the insulinotropic compound ferulic acid, is a candidate for this effect. Therefore, it is reasonable to assume that the prevalence of diabetes or at least a prediabetic (type 2) situation can be ameliorated by the investigated rice bran extract. The potential usefulness of the extract as a nutraceutical is currently undergoing more thorough investigations. Copyright (c) 2012 John Wiley & Sons, Ltd.