Peptide YY and cancer: current findings and potential clinical applications
Peptide YY and cancer: current findings and potential clinical applications
复制标题
DOI：
10.1016/s0196-9781(01)00616-7
复制
发表时间：
2002-02-01
期刊：
影响因子：
3
通讯作者：
Liu, CD
中科院分区：
文献类型：
--
作者：
Tseng, WW;Liu, CD
肽YY （PYY）是一种天然存在的肠道激素，主要对多个组织靶点起抑制作用。PYY已在几种类癌中被发现，PYY表达的降低可能与结肠腺癌的发生和发展有关。PYY治疗可以减少胰腺和乳腺肿瘤的生长，很可能是通过降低细胞内cAMP。在癌症患者中。PYY还可以改善由医源性原因或与晚期疾病相关的恶病质引起的营养不良。PYY在癌症的多个方面发挥着重要作用，从调节细胞生长到潜在的治疗应用。(C) 2002爱思唯尔科学有限公司版权所有。
Peptide YY (PYY) is a naturally occurring gut hormone with mostly inhibitory actions on multiple tissue targets. PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. Treatment with PYY decreases growth in pancreatic and breast tumors, most likely through a reduction in intracellular cAMP. In cancer patients. PYY may also improve malnutrition that results from iatrogenic causes or cachexia associated with advanced disease. PYY plays a significant role in multiple aspects of cancer from regulation of cell growth to potential therapeutic applications. (C) 2002 Elsevier Science Inc. All rights reserved.