Transplantable Human Neoplasms Maintained in Cortisonetreated Laboratory Animals: H.S.
Transplantable Human Neoplasms Maintained in Cortisonetreated Laboratory Animals: H.S.
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可的松处理的实验动物中维持的可移植人类肿瘤：H.S.
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
R. Blanden
中科院分区：
文献类型：
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作者：
Frank M. Collins;G. Mackaness;R. Blanden
在之前的一篇论文(7)中，人们注意到人类表皮样癌的活体标本最初被植入皮下注射可的松治疗的大鼠体内，在皮质化肛门移植的第8代和第9代如此增加，以至于它被150只大鼠和仓鼠携带。人们希望这个肿瘤成为人类可移植肿瘤系列中的第一个，这一愿望自H.Ep以来已经实现。1号(人类表皮样癌1号，现在被命名为1号)正处于组织培养中批量生产的第18个月。在首次报道了在实验室动物中可常规移植的人类肿瘤之后，对其他人类癌症进行了初步的描述(8，9)，这些癌症已经发展到可以作为可移植肿瘤用于实验姿势的程度。其中两种肿瘤，一例软组织肉瘤(H.S.#1)，现已转移16个月，以及一例表皮样癌(H.Ep。#3)，已经被转移了5个月以上，生长得如此之快，以至于它们在植入后10-15天杀死了动物宿主。在这短短的一段时间内，它们的质量可能增加多达80倍，甚至100倍。这两种肿瘤都在大量生产，并在本研究所和全国各地的实验室广泛使用。出于这个原因，将对它们进行更详细的描述。另外三种癌症，最初的表皮样癌已经发生(H.Ep.#1)，以及另一种命名为H.Ep的表皮样癌。#2和胚胎性横纹肌肉瘤(H.Emb.Rh.#1)增长率较适中，目前使用有限。它们将作为一种
In a previous paper (7) it was noted that a biop sy specimen of a human epidermoid carcinoma, originally implanted subcutaneously in a single cortisone-treated rat, had so increased by the 8th and 9th transfer generations in cortisonized ani mals that it was being carried by 150 rats and hamsters. It was hoped that this tumor would be come the first of a line of transplantable human neoplasms, a wish which has been fulfilled, since H.Ep. #1 (human epidermoid carcinoma #1, as it is now designated) is in its 18th month of quantity production in tissue culture. Subsequent to this first report of a human tu mor regularly transplantable in laboratory ani mals, preliminary accounts (8, 9) were given of other human cancers which had been developed to the point where, as transplantable tumors, they could be employed for experimental pur poses. Two of these neoplasms, a soft part sarcoma (H.S. #1), which has now been transferred for 16 months, and an epidermoid carcinoma (H.Ep. #3), which has been transferred for more than 5 months, are growing so vigorously that they kill their animal hosts 10-15 days after implantation. Within this short period they may increase as much as 80or even 100-fold in mass. Both tumors are being produced in large quantities and are in wide use in this Institution and in laboratories throughout the country. For this reason, they will be described in some detail. Three other cancers, the original epidermoid carcinoma already men tioned (H.Ep. #1), as well as another epidermoid carcinoma designated as H.Ep. #2 and an embry onal rhabdomyosarcoma (H.Emb.Rh. #1) have a more moderate growth rate and are in limited use at present. They will be mentioned briefly as a