Acute nonlymphocytic leukemia: expression in cells restricted to granulocytic and monocytic differentiation.
Acute nonlymphocytic leukemia: expression in cells restricted to granulocytic and monocytic differentiation.
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急性非淋巴细胞白血病：在粒细胞和单核细胞分化受限的细胞中表达。
DOI：
10.1056/nejm197907053010101
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
J. Moohr
中科院分区：
文献类型：
--
作者：
P. Fialkow;J. Singer;J. Adamson;R. Berkow;J. Friedman;R. Jacobson;J. Moohr
对两例X染色体连接酶葡萄糖-6-磷酸脱氢酶杂合子的急性非淋巴细胞白血病患者进行了研究，以确定发病细胞的数量和类型。在正常组织中发现A型和B型两种同工酶，但成髓细胞只有一种酶类型，这表明在研究时，该病是克隆起源的。在一名患者身上观察到的红系细胞不是从这个克隆中产生的，这与之前用染色体标记研究的患者得出的结论形成了对比。结果表明，在这例患者中，白血病克隆抑制了正常粒系的表达，但不抑制正常祖细胞的红系分化。他们还表明，这种疾病是异质性的。在一些患者中，这种疾病表现在分化受限于粒细胞-巨噬细胞途径的细胞中；在另一些患者中，它涉及也分化为红细胞的干细胞。这种异质性可能反映了因果关系的不同，并可能具有预后重要性。
Two patients with acute nonlymphocytic leukemia who were heterozygous for the X-chromosome-linked enzyme glucose-6-phosphate dehydrogenase were studied to determine the number and type of cells in which the disease arises. Both type A and B isoenzymes were found in normal tissues, but the myeloblasts showed only one enzyme type, indicating that at the time of study, the disease had a clonal origin. The observation in one patient that erythroid cells did not arise from this clone contrasts with conclusions reached in patients previously studied with chromosomal markers. The results suggest that in this patient, the leukemic clone suppressed expression of normal granulopoiesis but did not inhibit erythroid differentiation from normal progenitors. They suggest also that the disease is heterogeneous. In some patients, the disease is expressed in cells with differentiation restricted to the granulocyte-macrophage pathway; in others, it involves stem cells that also differentiate into erythrocytes. This heterogeneity may reflect differences in causation and could have prognostic importance.