Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes.
Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes.
复制标题
促肾上腺皮质激素释放激素影响人 HaCaT 角质形成细胞中细胞因子的产生。
DOI：
10.1016/s0024-3205(01)01476-x
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发表时间：
2002
期刊：
影响因子：
6.1
通讯作者：
J. Myśliwska
中科院分区：
文献类型：
--
作者：
B. Zbytek;A. Myśliwski;A. Slominski;J. Wortsman;E. Wei;J. Myśliwska
CRH的皮肤表达在暴露于各种刺激后显著增强(Physiol Rev 2000，80；979-1020)。我们评估了CRH对HaCaT角质形成细胞产生细胞因子的影响，HaCaT角质形成细胞系表达CRH受体，偶联cAMP激活和钙依赖的传递途径。首次证实外源性CRH可刺激IL-6和IL-11的产生。它还抑制IL-1β的产生，不影响肿瘤坏死因子-α的产生。我们的结果表明，促肾上腺皮质激素释放激素在皮肤应激中的作用(S)可能是通过对细胞因子产生的不同影响而介导的。
CRH cutaneous expression is significantly enhanced after exposure to various stimuli (Physiol Rev 2000, 80;979–1020). We evaluated the effect of CRH on cytokine production in HaCaT keratinocytes, a cell line shown to express CRH receptors coupled to cAMP activation and calcium-dependent transmission pathways. It is demonstrated for the first time that exogenously added CRH stimulates production of IL-6 and IL-11. It also inhibits production of IL-1beta and does not affect TNF-alpha production. Our results indicate that CRH function(s) during cutaneous stress may be mediated by differential effects on cytokine production.