Excitability changes in the left primary motor cortex innervating the hand muscles induced during speech about hand or leg movements
Excitability changes in the left primary motor cortex innervating the hand muscles induced during speech about hand or leg movements
复制标题
在关于手或腿运动的演讲中引起手部肌肉神经支配的左初级运动皮层的兴奋性变化
DOI：
10.1016/j.neulet.2015.03.052
复制
发表时间：
2015
影响因子：
2.5
通讯作者：
Kozo Funase
中科院分区：
文献类型：
--
作者：
Yusuke Onmyoji;Shinji Kubota;Masato Hirano;Megumi Tanaka;Takuya Morishita;Kazumasa Uehara;Kozo Funase
在本研究中，我们使用经颅磁刺激（TMS）调查的兴奋性的变化，左侧初级运动皮层（M1）支配的手肌肉和短间隔皮层内抑制（SICI）在语音描述的手或腿的运动。实验一探讨了言语内容对阅读和默读阅读时运动诱发电位（MEP）幅值的影响。在实验2中，我们重复实验1的附加条件，非声乐口腔运动（No-Voc OM）的条件，并研究了在每个条件下使用配对TMS范式引起的SICI的变化。在阅读和无语音OM条件下观察到的MEP表现出比在无声阅读条件下观察到的MEP显著更大的幅度，与受试者说出的句子的内容或TMS的时间无关。实验条件之间的SICI没有显著差异。我们的研究结果表明，在讲话过程中检测到的左手M1区的兴奋性增加，主要是由语音相关的口腔运动和语言处理相关的大脑功能的激活引起的。左侧M1兴奋性的增加可能也是由SICI降低以外的神经机制介导的;即，去抑制
In the present study, we used transcranial magnetic stimulation (TMS) to investigate the changes in the excitability of the left primary motor cortex (M1) innervating the hand muscles and in short-interval intracortical inhibition (SICI) during speech describing hand or leg movements. In experiment 1, we investigated the effects of the contents of speech on the amplitude of the motor evoked potentials (MEPs) induced during reading aloud and silent reading. In experiment 2, we repeated experiment 1 with an additional condition, the non-vocal oral movement (No-Voc OM) condition, and investigated the change in SICI induced in each condition using the paired TMS paradigm. The MEP observed in the reading aloud and No-Voc OM conditions exhibited significantly greater amplitudes than those seen in the silent reading conditions, irrespective of the content of the sentences spoken by the subjects or the timing of the TMS. There were no significant differences in SICI between the experimental conditions. Our findings suggest that the increased excitability of the left M1 hand area detected during speech was mainly caused by speech-related oral movements and the activation of language processing-related brain functions. The increased left M1 excitability was probably also mediated by neural mechanisms other than reduced SICI; i.e., disinhibition.